摘要
目的探讨结直肠癌患者外周血前列腺素E2(PGE2)和血清可溶性白细胞介素-2受体(sIL-2R)在手术前后的动态变化及临床意义。方法 61例结直肠癌患者按是否有转移分成2组,无远处转移组46例,远处转移组15例,其中根治性切除41例,姑息性切除11例,剖腹探查9例,对照组为健康体检者。分别检测患者手术前后外周血PGE2s、IL-2R和CD4+、CD8+含量。结果结直肠癌患者术前外周血PGE2和sIL-2R水平明显升高,同时白细胞介素2(IL-2)水平和CD4+/CD8+值降低,IL-2与sIL-2R和PGE2呈显著负相关,手术切除原发肿瘤后PGE2和sIL-2R水平显著下降,同时IL-2水平和CD4+/CD8+值升高,其中,根治组和对照组相比术后差异无统计学意义,姑息性切除组和剖腹探查组术后外周血PGE2和sIL-2R水平仍高于正常。结论 PGE2和sIL-2R参与了结直肠癌患者术前存在的免疫抑制过程,结直肠癌患者外周血PGE2和sIL-2R水平动态检测可视为结直肠癌根治术后是否复发或转移的辅助指标。
Objective To determine the dynamic change of the levels of peripheral blood PGE2 and sIL-2R in patients with colorectal carcinoma pre-and post-operation and the clinical significance.Methods 61 patients with colorectal carcinoma were recruited in the study,15 cases had simultaneously distant metastasis,and 46 patients did not show any obvious distant metastasis.11 patients underwent palliative resection and 9 patients received laparotomy.41 patients received resection.Healthy individual at physical examination were considered as controls.The levels of peripheral blood PGE2,sIL-2R,CD4＋ and CD8＋ pre-and post-operation in 61 patients with colorectal carcinoma were assayed respectively.Results The patients with colorectal cancer had a high concentration of peripheral blood PGE2 and sIL-2R before operation.The levels were considerably higher than the normal in this study.But the level of IL-2 and CD4＋/CD8＋in peripheral blood were lower than the control group before surgical operation.The peripheral blood PGE2 and sIL-2R had a negative correlation with IL-2.The levels of sIL-2R and PGE2 were lower after the original tumor was resected and the levels of IL-2 and CD4＋/CD8＋ were higher after operation than that before operation,the levels of PGE2 and sIL-2R decreased almost to normal in the patients with radical resection,but were still higher in those with palliative resection.Conclusions PGE2 and sIL-2R participate in the immunologic hypofunction existing in the patients with colorectal carcinoma before operation.The level of peripheral blood PGE2 and sIL-2R may be considered as an auxiliary monitor maker of whether recurrence of distant metastasis has developed after radical resection.
出处
《中华疾病控制杂志》
CAS
2011年第8期648-651,共4页
Chinese Journal of Disease Control & Prevention
基金
2008年度合肥市科技局重大课题(2008-46)
