摘要
为探讨胃液表皮生长因子（EGF）含量变化及幽门螺杆菌（Hp）感染与胃十二指肠疾病的相关性。以幽门螺杆菌感染阳性的78例消化性溃疡和61例慢性胃炎患者为研究对象，健康人20例作对照，观察胃液EGF含量变化与胃十二指肠疾病的相关性。结果发现，消化性溃疡和慢性胃炎患者胃液EGF含量分别为175．1±103．5ng／L和240．9±182．1ng／L，明显低于正常人，511.9±54．1ng／L，（均P＜0.01）。消化性溃疡患者EGF含量明显低于慢性胃炎患者，P＜0．01。具有CagA基因的Hp感染的消化性溃疡患者EGF含量明显低于慢性胃炎组，P＜0．05。表明胃液EGF含量与Hp感染有关，尤其是具有CagA基因的幽门螺杆菌感染。
In order to evaluate the correlation between epidermal growth factor (EGF) in gastric juice and the infectionwith Helicobacter pylori in patients with gastroduodenal diseases, the levels of epidermal growth factor (EGF) ingatric juice were studied in seventy eight patients with peptic ulcer and sixty one patients with chronic gastritis, whowere all diagnosed as infected with Helicobacter pylori (Hp), and twenty healthy volunteers as controls. The resultsshowed that the EGF levels were significantIy lower in peptic ulcer and gastritis groups than those in the controls(175.1±103.5ng/L, 240.9 ±182.1 ng/L, and 511 .9 ± 54.1ng/L respectively, P<0.01 ). The EGF levels in CagA+Hpinfected patients with peptic ulcer were also lower than those in CagA+Hp infected subjects with gastritis (P<0.05).The srsults suggest that EGF level in gastric juice is related to Hp infection, especially to the CagA+Hp infections.
出处
《基础医学与临床》
CSCD
2000年第3期56-57,共2页
Basic and Clinical Medicine
关键词
消化性溃疡
慢性胃炎
幽门螺杆菌
CAGA基因
EGF
peptic ulcer
chronic gastritis
Helicobacter pylori
epidermal growth factor
CagA gene
