摘要
目的 探讨肺癌的发病机理 ,提高检测阳性率 ,为临床的早期诊断、治疗提供依据。方法 用放射免疫分析的方法 ,检测肺癌患者血清及胸水中NSE、CYFRA2 1 1、CEA的水平。结果 肺癌组与肺良性疾病和正常对照组血清当中NSE、CYFRA2 1 1、CEA的水平比较有显著性差异 ;各型肺癌患者胸水中NSE的阳性率从大到小依次为小细胞肺癌、未定型癌、鳞癌、腺癌 ;而小细胞肺癌阳性率最高与其它型肺癌比较有显著性差异 ;CYFRA2 1 1阳性率以腺癌和鳞癌最高 ,与另两型比较有显著性差异P <0 0 1;胸水与血清当中三项指标的阳性率和升高幅度比较 ,前者明显高于后者 ,三项联检要比单项检测的阳性率显著提高。结论 肺癌患者血清及胸水中NSE、CYFRA2 1 1、CEA水平变化与其肺癌的病理类型密切相关 。
Objective To explore the mechanism of lung tumor and to enhance the detection ratio.Methods Serum and pleural fluid NSE,CYFRA21 1 and CEA were assayed by RLA Results The positive ratio of NSE in pleural fluid was ordered by small cell lung carcinoma>undifferentiated carcinoma>squamocellular carcinoma>adenoma,with stastical significance in small cell lung carcinoma;while for CYFRA21 1,positive ratio in serumbeing with stastical significance in adenoma and squamocellular carcinoma.For positive ratio and evalated altitude,all the indice in pleural fluid wrer higher than those in serum.Combined detection with three indice will improve positive ratio.Conclusion In patients with lung tumor,NSE,CYFRA21 1 and CEA in plerual fluid and serum were related to pathological type,combined detection will improve positive detection.
出处
《肿瘤防治研究》
CAS
CSCD
北大核心
2000年第3期172-174,共3页
Cancer Research on Prevention and Treatment
