摘要
为研究NSE在肺癌诊断、疗效监测和预后观察的临应意义及应用价值,本文对129例肺癌病人和54例肺部良性疾病患者,应用免疫放射分析法(IRMA)检测NSE的血清含量。肺癌病人平均血清水平30.1±30.9ng/ml,良性病人平均13.4±6.2ng/ml(p<0,01),两组差异显著。肺癌病人平均阳性检出率55％,其中肺小细胞癌病人阳性率是87.5％(27/32),鳞癌和腺癌阳性率分别为47.5％和41.9％,良性病人假阳性率为35.2％。测定灵敏度为55％,特异性65.5％,准确率58.0％。肺癌病人治疗后的NSE平均水平从治疗前的62.6土50.9ng/ml降至19.4±17.6ng/ml,11例治疗有效病人血清水平均有不同程度下降,2例治疗无效者,血清NSE水平增高。提示NSE对肺癌诊断有一定的临床价值,尤其对肺小细胞癌的诊断、疗效鉴定及预报复发意义更大。
Serum NSE contents were determined by immunoradiometric assay in 129 patients with pulmonary carcinoma and 54 patients with benign lung diseases to evaluate its significance in diagnosis, appraising therapeutic value and prognosis for pulmonary carcinoma. The average serum NSE level of patients with pulmonary carcinoma was 30.1±30.9ng/ml, and that of patients with benign lung diseases was 13.4±6.2ng/ml,the difference being significant (p<0.01). The average positive rate in patients with pulmonary carcinoma was 55% being 87.5%(27/32)for small cell lung cancer, 47.5% for squamouse cell carcinoma and 41.9% for adenocarcinoma respectively. The false positive rate for patients with benign lung diseases was 35.2%. The sensitivity, specificity and accuracy of NSE determination in pulmonary cancer patients were 55%, 65.5% and 58.0% respectively. The NSE level of patients with pulmonary carcinoma decreased from 62.6±50.9ng/ml to 19.4±17.6ng/ml after chemotherapy. 11 patients with satisfactory therapeutic effect had different degree of decrease of serum NSE level, the other 2 patients with poor therapeutic effect had increases of serum NSE level. It instead was demonstrated that NSE had relatively accurate clinical significance in diagnosis for pulmonary carcinoma, specially for small cell lung cancer.
出处
《放射免疫学杂志》
CAS
1998年第5期257-259,共3页
Journal of Radioimmanology
