摘要
目的从免疫学方面探讨汉丹肝乐抗肝纤维化的作用。方法慢性肝炎、早期肝硬化病人41例服用汉丹肝乐 1 6g,每日 3次 ,三个月为一个疗程 ,收集治疗前后静脉血分离血清检测TNF a(肿瘤坏死因子 )、sIL 2R(可溶性白细胞介素 2受体 )、SOD(超氧化物歧化酶 )、SF(血清铁蛋白 )、Ig(免疫球蛋白 )、C3 水平。结果慢性肝炎、早期肝硬化患者血清TNF a、sIL 2R、SF、IgM、IgG、LgA均升高 ,C3、SOD降低。予汉丹肝乐治疗一个疗程后TNF a、sIL 2R、SF、LgM、LgG、LgA降低 ,C3、SOD升高 ,治疗前后对比差异有显著意义 (P <0 0 5 )。结论汉丹肝乐能保护肝细胞 ,增强免疫调节功能 ,抑制胶原的产生和沉积 ,从而具有抗肝纤维化的作用。
Objective [WT5”BZ]To investigate the effect of Han-Dan-Gan-Le anti-hepatic fibrosis. [WT5”HZ]Methods [WT5”BZ]41 patients with chronic hepatitis and early hepatic cirrhosis took Han-Dan-Gan-Le 1.6g, three times one day, 3 months as a course of treatment. The level of TNF-α,sIL-2R,SOD,SF,Ig and C 3 in serum were detected before and after the treatment. [WT5”HZ]Results [WT5”BZ]TNF-α,sIL-2R,SF,IgM, IgG and IgA of serum were raised, C 3 and SOD decreased in patients with early hepatic cirrhosis and chronic hepatitis. TNF-α,sIL-2R,SF,IgM, IgG, IgA were reduced after one course of treatment by giving Han-Dan-Gan-Le, C 3 and SOD raised. The comparison between post-treatment and pre-treatment was obviously different ( P <0.05). [WT5”HZ]Conclusion [WT5”BZ]Han-Dan-Gan-Le could protect hepatic cells , strengthen immunoregulatory effect, inhibit production and deposit of collagen, so it has the effect of anti-hepatic fibrosis. [WT5”HZ]
出处
《贵州医药》
CAS
2000年第6期331-332,共2页
Guizhou Medical Journal
