摘要
多中心协作统一使用国产血清Ⅲ型前胶原放射免疫分析试剂盒，测定１１９９例（份）采自正常对照和各种肝病病人血清标本。结果：肝硬化和慢性活动肝炎组血清ＰＣⅢ显著升高（Ｐ＜０．００１），急性肝炎略有升高，慢性迁延性肝炎等其它各组均不升高。９０例同时测定血清ｐⅢＰ、胆红素、ＡＬＴ、白蛋白和ＨＢＶＤＮＡ，血清ＰＣⅢ与ＰⅢＰ相关外，与其它指标不相关。对３７例肝活检中肝纤维化进行了分级，血清ｐｃⅢ与肝纤维化程度呈正相关（ｒ＝０．９８４，ｐ＜０．００１）。结论认为此试剂盒论断肝纤维化的价值是肯定的。
The Procollagen type(PC
Ⅲ)radioimmunoassay kit established by Chongqing Cancer Institute
wasused by multiple cooperative centers to determine PCⅢ serum
levels of 1 1 99 cases with normal con-trols and varied liver
diseases.The results show that serum PCⅢ levels were: signifcantly
raised(P<0.001)in the patients with hepatic cirrhosis and chronic
active hepatitis, siightly raised in the patients with acutehepatitis
and not raised in the patients with chronic persistent hepatitis and
other varied groups. Serum、P ⅢP,bilirubin,ALT, albumin and HBV DNA
were simultaneously determined in9Ocases.The serum PC Ⅲ level was
related to serum P Ⅲ P),but not to allother parameters. The hepatic
fibrosis was close relation-ship(r= 0.984;P<0.001) between the grade
of hepatic fibrosis and serum PCⅢ level.The results suggestthat
this kit has definite value in the diagnosis of hepatic fibrosis.
关键词
Ⅲ型前胶原
放射免疫法
肝纤维化
诊断
Procollagen type Ⅲ Radioimmunoassay Hepatic fibrosis Hepatic
cirrhosis
