摘要
目的:本文研究不同部位泥鳅冻干粉对小鼠四氯化碳肝损伤的保护作用,筛选有效部位。方法:采用小鼠四氯化碳急性肝损伤模型,测定小鼠血清ALT、AST活性,观察泥鳅不同部位冻干粉的保护作用。结果:泥鳅全冻干粉和泥鳅肌肉冻干粉显著降低小鼠血清中ALT、AST活性(P<0.05),而泥鳅皮冻干粉的作用不明显(P>0.05)。结论:泥鳅冻干粉对小鼠四氯化碳肝损伤具有显著的保护作用,其中泥鳅全冻干粉的作用最明显,是泥鳅保肝的主要有效部位。
Objective：To investigate different dosing position of Misgurnus Anguillicaudatus lyophilized power on chemical liver injury in mice induced by CCl4,screening of the best effective part.Methods：A mouse model of acute liver injury was induced by carbon tetrachloride,determining of serum ALT and AST activities so as to observe different parts of Misgurnus Anguillicaudatus lyophilized power protective effect.Results：Misgurnus Anguillicaudatus whole lyophilized power and muscle lyophilized power can significantly reduce the mice serum ALT and AST activities（P0.05）,but Misgurnus Anguillicaudatus skin lyophilized power had no apparent effect（P0.05）.Conclusion：The Misgurnus Anguillicaudatus lyophilized power had significant effect on mice liver injury induced by carbon tetrachloride.The effect of Misgurnus Anguillicaudatus whole lyophilized power is most obvious,which is the main effective part of liver protection.
出处
《辽宁中医药大学学报》
CAS
2013年第1期53-54,共2页
Journal of Liaoning University of Traditional Chinese Medicine
基金
江苏省水产三项工程项目(PJ2011-62)
连云港市赣榆县泥鳅协会项目(P113400310)
关键词
泥鳅
冻干粉
肝损伤
Misgurnus Anguillicaudatus
lyophilized power
hepatic injury
