摘要
应用蓖麻凝集素(RCA)以ABC亲和细胞化学方法标记原发性肝癌组织,其RCA受体阳性率为86.4％(57/66),其中肝细胞癌63例,胆管上皮癌3例,其阳性率分别为85.7％(54/63)和100.0％(3/3),而对照组包括10例正常肝组织,9例肝炎,22例肝硬化的肝细胞均无RCA受体表达。作者认为,RCA受体出现是原发性肝癌重要标记之一。结果表明,RCA受体阳性率与肝细胞癌分化程度或排列方式无明显关系,但RCA受体分布型式与肿瘤分化程度似乎有一定关系,提永低分化肝细胞癌糖基可能更加紊乱。本文结果还显示,癌旁宿主部分肝细胞RCA受体呈阳性,这种化学结构异常先于形态学改变,对于认识癌前病变及诊断也有重要意义。
The binding of RcA to paraffin sections of sixty-six primary liver carcinoma and forty-one non-neoplastic liver tissue was examined by the ABC immunohistochemical method. The positive staining reaction of RcA receptor was recognized by the occurrenceof brown granular reaction product in the cytoplasm or on the cell menbrane. The positive rate in 66 cases of primary liver carcinoma was 86.4% (57/66). In 10 cases of normal liver tissue, in 9 cases of hepatitis and 22 cases of liver cirrhosis, RcA binding was all negative. These results suggest that RcA binding might be used as a new method for the diagnosis and differential diagnosis of primary liver carcinoma. The study showed that RcA receptor distribution is related to the differentiation of liver carcinoma. There was no relation between the RcA positive rate and the differentiation of liver carcinoma. The positive reaction was observed in the liver cells surrounding the cancer. A conclusion can be made that these RcA receptor positive liver cells might be a precanerous lesion of primary liver carcinoma.
出处
《癌症》
SCIE
CAS
CSCD
北大核心
1991年第1期16-18,共3页
Chinese Journal of Cancer
关键词
肝肿瘤
蓖麻凝集素
受体
Primary liver carcinoma Ricinus communis agglutinin Receptor.
