摘要
目的探讨非酒精性脂肪肝(NAFLD)患者发生2型糖尿病的危险因素。方法本院收治的非酒精性脂肪肝患者68例,包括非酒精性脂肪肝伴初诊2型糖尿病患者35例(实验组)和单纯性非酒精性脂肪肝患者33例(对照组)。比较2组患者性别、年龄、体质量指数(BMI)、血压、糖尿病家族史及吸烟史、甘油三酯(TG)、胆固醇(CHOL)、低密度脂蛋白(LDL)、高密度脂蛋白(HDL)、载脂蛋白(APOAI)、谷丙转氨酶(ALT)、谷草转氨酶(AST)、γ-谷氨酰转肽酶(GGT)、碱性磷酸酶(ALP)、空腹静脉血浆葡萄糖(FBG)、血清胰岛素(FNS)。结果对照组中吸烟人数、有糖尿病家族史人数的比例明显低于实验组(P<0.01)。2组BMI、FBG、FNS、TG、CHOL、LDL、HDL、APOAI、ALT水平差异有统计学意义(P<0.01)。结论吸烟、糖尿病家族史、BMI、FBG、FNS、TG、CHOL、LDL、HDL、APOAI、ALT为影响NAFLD患者发生2型糖尿病的危险因素。
Objective To explore the risk factors of non-alcoholic fatty liver disease （NAFLD） in patients with type II diabetes. Methods 68 patients with non-alcoholic fatty liver were randomly divided into 2 groups： 35 cases of non-alcoholic fatty liver combined with type Ⅱ diabetes were designed as experimental group, and 33 cases of simple non-alcoholic fatty liver were de- signed as control group. The gender, age, body mass index （BMI）, blood pressure, family history of diabetes and history of smoking, triglyceride （TG）, cholesterol （CHOL）, low-density lipopro- tein （LDL）, high density lipoprotein （HDL）, apolipoprotein （APOAI）, alanine aminotransferase （ALT）, aspartate aminotransferase （AST）, gamma-glutamyl GGT （GGT）, alkaline phosphatase （ALP）, fasting venous plasma glucose （FBG）, serum insulin （FNS） were compared between 2 groups. Results The number of smokers and the ratio of family history of diabetes in the control group were significantly lower than that in the experimental group （P 〈 0.01 ）. Differences on BMI, FBG, FNS, TG, CHOL, LDL, HDL, APOAI, ALT levels between 2 groups were statistical significance （P 〈 0.01）. Conclusion Smoking, family history of diabetes, BMI, FBG, FNS, TG, CHOL, LDL, HDL, APOAI, ALT are the risk factors for onset of type Ⅱ diabetes in NAFLD patients.
出处
《实用临床医药杂志》
CAS
2012年第23期51-53,共3页
Journal of Clinical Medicine in Practice
基金
中国高校医学期刊临床专项资金(11220241)
