摘要
目的探讨糖化血红蛋白（HbAlc）和N末端脑钠肽原（NT—pmBNP）与急性冠脉综合征（ACS）患者心功能的相关性。方法选择53例ACS合并2型糖尿病（T2DM）（T2DM组）和67例ACS（ACS组）作为研究对象，采用免疫比浊法检测HbAlc水平，电化学发光法测定NT．proBNP含量并比较。结果T2DM组HbAlc、NT．proBNP分别为（9．21±1．23）％、（3．56±1．12）ng／ml，均高于ACS组的（5。09±0．67）％、（0．14±0．04）ng／ml（t=6．495、9．277，均P〈0．01）；ACS患者心功能与HbAlc、NT—proBNP呈正相关性（r=0．517、0．589，均P〈0．01），ACS患者HbAlc与NT．proBNP之间也呈正相关性（r=0．431，P〈0．05）。结论HbAlc和NT—proBNP对ACS患者心功能损伤有促进作者，可作为ACS心功能受损的诊断指标。
Objective To investigate the correlation between glycosylated hemoglobin（ HhAl c）, plasma NT- proBNP and the cardiac function in patients with acute coronary syndrome （ACS）. Methods 53 patients with both ACS and type 2 diabetes mellitus （T2DM） （T2DM group） ,67 patients with ACS（ ACS group） were selected as the objects. The HbAlc level was detected by immunohistochemical than turbidimetry, and the content of NT-proBNP was detected by electrochemiluminescence method. Results The levels of HbAlc ,plasma NT-proBNP of the T2DM group were（9.21 ± 1.23 ）%, （3.56 ± 1. 12 ）ng/ml, respectively, which were higher than those of ACS group [ （5.09 ± 0. 67 ） %, （0.14±0.04） ng/ml ] （ t = 6.495,9.277, all P 〈 0.01 ） ; The cardiac function of ACS patients was positive- ly correlated with the levels of HbA1 c and plasma NT-proBNP（ r = 0.517,0.589, all P 〈 0.01 ）, and there was posi- tive correlation between the levels of HbAlc and plasma NT-proBNP in ACS patients （ r = 0. 431, P 〈 0. 05 ）. Conclusion The HbAlc and NT-proBNP can promote the injury of the cardiac function of ACS patients, and can he used as diagnostic indicators of the injury of the cardiac function of ACS patients.
出处
《中国基层医药》
CAS
2012年第23期3541-3542,共2页
Chinese Journal of Primary Medicine and Pharmacy
