摘要
目的探讨炎症与房颤发生与维持的关系。方法研究对象为40例风湿性心脏病接受换瓣手术者,按病史及心电图表明的心律情况分为二组,窦性心律组22例,慢性房颤组18例。以免疫组织化学方法定性测定NF-κB表达及分布;用EMSA方法测定NF-κB蛋白含量。结果与窦性心律组比较,慢性房颤组心房组织中NF-κB明显增加(P<0.01)。结论慢性房颤患者心房组织中NF-κB的表达增加,可能是房颤时炎症参与的证据之一。
Objective To depict the interaction between atrial fibrillation （AF） and inflammatory reaction, studies were tak- en to measure the activity of NF-κB in myocardium, the concentration of regional inflammatory factors and the pathological process of the right atrium in patients with AF. Methods Patients with valvular disease with AF or sinus rhythm （SR） were recruited and compared. The activity of NF-κB in myocardium was measured by electrophoretic mobility shift assay（EM- SA）. Results Patients with valvular disease with AF exhibited higher NF-κB activity than those patients with valvular dis- ease with SR. There were significant positive correlations among NF-κB activity. Conclusion This study proved the pres- ence of inflammation in atrial myocardium by triggering inflammatoryreaction.
出处
《中国现代医生》
2012年第32期44-45,48,共3页
China Modern Doctor
