摘要
目的 探讨新生儿脐血HbA(α_2β_2定量与β-Thal之间的关系。方法 用美国Helena实验公司的全自动快速电泳分析系统(REP)对911例新生儿脐血进行Hb电泳和血常规检查。结果 以父母至少一方为β-Thal患者,其足月脐HbA定量<12％为标准,筛选出的51例疑β-Thal新生儿,经随访证实,有43例为β-Thal,检出率达84.3％。结论 以父母至少一方为β-Thal患者,其足月脐血HbA定量<12％两个指标,结合血常规检查,可作为早期诊断婴儿轻型β-Thal的重要依据。
Objective To investigate the relation between β-Thal and Hemoglobin (HbA) level of neonatal cord blood. Method Hb electrophoresis of 911 neonatal cord blood samples was done by Rapid Electrophoresis System (REP) (Helena Laboratories. U. S. A. ), as well as the complete blood count. Result 51 of the 911 cases were suspected to be β-Tha,by screening using the following criteria : the neonatal cord blood HbA<12% and at least one of their parents is a β-Thal. After following-up of these cases. 43 cases (84.3%) were verified to be β-Thal. Conclusion If one of the parents is a β-Thal. and neonatal cord blood HbA<12% at birth, the early diagnosis of mild ,β-Thal can be made in newborns combined with the complete blood count.
