摘要
目的研究不同类型珠蛋白生成障碍性贫血(简称地贫)患者中葡萄糖-6-磷酸脱氢酶(G6PD)的活性。方法采用G6PD活性定量测定,血常规和血清铁蛋白检测对人群进行初筛,同时采用全自动琼脂糖凝胶电泳检测初筛人群的α-地贫以及β-地贫类型,并对其G6PD活性值进行相关统计学分析。结果健康人群、单纯缺铁性贫血、缺铁性贫血合并地贫、轻型α-地贫、轻型β-地贫、重型β-地贫、血红蛋白H(HbH)病以及α-地贫合并β-地贫各组间G6PD活性差异有统计学意义(P<0.05)。结论各类型地贫患者的G6PD活性有不同程度的升高,对地贫的辅助诊断有一定的价值。
Objective To investigate the activity of glucose-6-phosphate dehydrogenase（G6PD） in patients with different types of thalassemia.Methods G6PD activity,blood cell counts and serum ferritin were detected for preliminary screening,and full-automatic agar gel analyzer was used to confirm the type ofα-or β-thalassemia.G6PD activity of all subjects were statistically analyzed.Results There were statistical difference of G6PD activity between healthy subjects and patients with iron deficiency anemia（IDA）,IDA combined thalassemia,α-thalassemia minor,β-thalassemia minor,β-thalassemia major,hemoglobin H（HbH） disease and αcombine β-thalassemia（P〈0.05）.Conclusion The G6PD activity in patients with various types of thalassemia might be increased for different degree.It might be with certain value for auxiliary diagnosis of thalassemia.
出处
《国际检验医学杂志》
CAS
2012年第11期1323-1324,共2页
International Journal of Laboratory Medicine
