摘要
目的探讨红细胞平均体积、红细胞脆性和血红蛋白电泳联合检测在地中海贫血诊断中的应用价值。方法对100例患病组(地贫患病组)和80例非地贫组(对照组)进行血细胞计数仪血常规测定、红细胞脆性检测、血红蛋白电泳仪进行血红蛋白电泳分析。结果MCV、红细胞脆性、Hb电泳单项检测对地中海贫血诊断的灵敏度及特异度分别为90.3%、77.5%、71.3%及70.1%、91.0%、91.8%;MCV、红细胞脆性、Hb电泳3项检测联合检测的灵敏度、特异度为100%、61.8%;经u检验,联合检测的灵敏度、特异度与单项检测相比,差异有统计学意义(P<0.05)。单项MCV、红细胞脆性和Hb电泳的阳性例数分别为91例、78例和71例,联合检测阳性数为68例。结论地中海贫血患者联合检测优于单项检测。
Objective To study the value of the combined tests of mean corpuscular volume,red cell osmotic fragility test and Hemoglobin electrophoresis for the diagnosis of thalassemia. Methods 100 cases in patients with thalassemia（sicken group） and 80 cases with control group were detected by complete blood count, red cell osmotic fragility, Hb electrophoresis and genetic test of thalassemia. Results The sensitivity and specificity of MCV ,RCOF,Hb electrophoresis single diagnostic test for thalassemia were 90.3% and 77.5% ,71.3% and 70.1%, 91.0%,91.8% ;Sensitivity and specificity of MCV, RCOF, Hb electrophoresis joint detection of 100%,61.8%;The joint detection of sensitivity and specificity of detection compared with the single, had a significant difference（ P〈 0.05 ）. Individual MCV, RCOF and Hb electrophoresis the number of positive cases were 91 cases,78 cases and 71 cases,The joint testing positive for the number of 68 cases. Conclusion Combined test is superior to each single test in patients with thalassemia.
出处
《中国现代医生》
2008年第31期124-125,共2页
China Modern Doctor
