摘要
目的:探讨老年2型糖尿病(T2DM)患者血清基质金属蛋白酶-9(MMP-9)水平与颈动脉内中膜厚度(IMT)的相关性。方法:老年T2DM患者66例,根据IMT分为3组:单纯糖尿病(DM)组18例,IMT增厚组23例,大动脉粥样硬化(AS)斑块组25例,另设老年健康对照组20例。测定血清MMP-9水平。结果:单纯DM组血清MMP-9水平为(576.43±257.93)μg.L-1,显著高于对照组的(387.70±243.71)μg.L-1(P<0.05);IMT增厚组和AS斑块组血清MMP-9水平分别为(694.58±315.26)、(882.74±286.44)μg.L-1,明显高于对照组和单纯DM组(均P<0.05)。结论:血清MMP-9水平升高与老年T2DM患者颈AS的病变程度密切相关。
Objective ： To investigated the association of serum matrix metalloproteinase- 9 （ MMP- 9） and carotid intima-media thickness （IMT） in elderly patients with type 2 diabetes mellitus （T2DM）. Methods： A total of 66 elderly patients with T2DM were recruited. These patients were further divided into 3 groups according to IMT. 18 cases of DM group, 23 cases of incrassation group and 25 cases of plaque group. 20 elderly healthy controls were selected. Serum level of MMP-9 were determined. Results： The serum MMP-9 in diabetic patients of DM group （576.43 ± 257.93 ） μg·L^-1 were higher than that in healthy controls （ 387.70 ± 243.71 ）μg·L^-1 （P 〈 0.05 ）. The diabetic patients of incrassation group （ 694.58± 315.26 ）μg·L^-1 and plaque group （ 882. 74 ± 286.44 ）μg· L^-1 were higher than that in DM group and healthy controls （ P 〈 0. 05 ）. Conclusion： The severity of carotid atherosclerosis（AS） in elderly patients with T2DM is closely associated with the increase of serum MMP-9.
出处
《现代医学》
2012年第6期688-690,共3页
Modern Medical Journal
