摘要肿瘤的发生是细胞增殖与凋亡相互作用的结果,其调控受细胞内外多种因素影响。凋亡抑制蛋白（inhibitor of apoptosis protein,IAP）是目前发现的唯一的可以和半胱氨酸天冬氨酸特异性蛋白酶（caspases）直接结合而起抑制作用的蛋白家族。它的过度表达引起的凋亡不足与肿瘤发生密切相关,同时在介导肿瘤化疗抵抗中发挥重要作用。
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