摘要
目的:探讨胃癌组织中凋亡抑制蛋白livin表达情况及其与临床病理因素的关系。方法:采用逆转录多聚酶链式反应(RT-PCR)检测胃癌组织中livinα、livinβmRNA的表达。结果:45例胃癌组织中RT-PCR检测livin表达阳性率为48.8%、,而在正常和癌旁组未检出阳性结果;livin的表达与组织分化和淋巴结转移有关,组织分化差,淋巴结转移者livin表达率高(P<0.05)。结论:livin在胃癌组织中表达增高,可作为胃癌的分子标志物,可能成为胃癌诊断和治疗的新分子靶点。
Objective ：To study the expression of livin, a novel inhibitor of apoptosis protein （lAP） family member, in human gastric carcinoma and to explore the relationship between livin expression and clinical parameters. Methods： The mRNA and protein expression of livin was detected in malignant, para - cancerous and benign gastric tissues respectively by reverse transcription polymerase chain reaction （RT- PCR）. Results： Livin mRNA was expressed in 22 out of 45 cases of gastric carcinoma （ 48.8% ）by RT -PCR. No livin expression was detected in para - cancerous or benign gastric tissues, there was a relationship between the expression of livin and degree of differentiation and metastases（P〈0.05） . Conclusion： Livin may serve as a new target for diagnose and therapy of gastric cancer.
出处
《现代肿瘤医学》
CAS
2008年第4期595-597,共3页
Journal of Modern Oncology
关键词
凋亡抑制蛋白
LIVIN
胃癌
inhibitor of apoptosis protein
livin
gastric carcinoma
