摘要
目的分析脉管癌栓对Ⅲ期胃癌手术患者预后的影响。方法回顾性分析422例Ⅲ期胃癌手术患者术后的临床及病理资料,其中脉管癌栓阳性者276例,阴性者146例。分析脉管癌栓阳性组与阴性组患者生存时间的差异及Ⅲ期胃癌患者预后的影响因素。结果脉管癌栓阴性患者的1年和3年生存率分别为84.9%和50%,脉管癌栓阳性组分别为69.6%和25.4%,差异有统计学意义(P均<0.01)。单因素分析显示:年龄、脉管癌栓情况、肿瘤的分化程度、Borrmann分型、T分期、N分期、淋巴结转移数、清扫的阴性淋巴结数是患者预后的影响因素。多因素分析筛选出脉管癌栓、Borrmann分型、N分期和阴性淋巴结数目等与Ⅲ期胃癌患者相关的独立预后因素(P均<0.01)。结论脉管癌栓是影响Ⅲ期胃癌患者预后的独立危险因素。
Objective The role of lymphovascular invasion on the prognosis of patients instageIIIgastric cancer was explored.Methods Retrospective analysis of clinical and pathological data from 422 cases of stage Ⅲ gastric cancer patients,showed 276 cases werelymphovascular invasion-positive and 146 cases were negative.Theoverall survival of stage III gastric patients betweenlymphovascular invasion-positive group and negative group were different,thereby prognostic factors were analyzed.Results In lymphovascular invasion-negative patients 1 year and 3year survival rates were 84.9% vs 50%,while in lymphovascular invasion-positive group 1 year and 3 year were 69.6% vs 25.4%,difference was statistically significant（P=0.001,P0.001）.Age,Lymphovascular invasion Tumor differentiation Borrmann classification,T stage,N stage,The number of negative lymph nodes were related with prognosis by Univariate analysis.Multivariate analysis showed that lymphovascular invasion,Borrmann type,N stage,and the number of negative lymph nodes were independent prognostic factorspredicting prognosis of stage III gastric cancer patients.Conclusion The lymphovascular invasion is an independent risk factor for stage III gastric cancer prognosis.
出处
《中国实用医药》
2012年第32期11-13,共3页
China Practical Medicine
关键词
胃癌
脉管癌栓
预后
Gastric cancer
Vascular invasion
Prognosis
