摘要
为研究IL-33在儿童急性免疫性血小板减少症(ITP)发病机制中的作用及意义,我们采用ELISA法检测了37名ITP患儿和37名对照者血清IL-33水平,分析IL-33与患儿就诊时血小板计数及后期疗效的关系。我们发现,ITP患儿血清IL-33较对照者明显增高(P<0.01),且与血小板计数呈负相关(R2=0.10,P=0.05)。血清IL-33水平与治疗效果密切相关,采用IL-33预测ITP患儿疗效,预测敏感性为0.88,特异性为0.81。这些结果提示:IL-33参与了ITP的发病机制,血清IL-33水平可以作为预测患儿疗效的免疫学指标。
To investigate the role of IL-33 in the pathogenesis of acute immune thrombocytopenia（ITP） and its potential clinicalsignificance, the serum IL-33 level in 37 ITP children and 37 healthy controls were detected by ELISA. The correlation between serum IL-33 level and platelet count and therapeutic outcome was analyzed. Increased serum IL-33 level （P〈0.01）, which negatively correlated with platelet count （R^2=.10,P=0.05）, was observed in ITP children. In addition, increased serum IL-33 was associated with poor therapeutic outcome. Thus it could be used as an effective predictive marker for therapeutic outcome, with a predictive sensitivity of 0.88 and specificity of 0.81. These results suggest that IL-33 involves in the pathogenesis of ITP and could be used as a predictive marker for therapeutic outcome.
出处
《现代免疫学》
CAS
CSCD
北大核心
2012年第6期506-509,共4页
Current Immunology
