摘要
目的探讨前列腺癌经直肠超声造影增强程度与部位的相关性。方法对150例前列腺癌可疑患者行经直肠超声造影检查，并运用时间-强度曲线分析软件对病灶增强的峰值强度（peak intensity，PI）进行定量测量，比较前列腺周缘区内侧、周缘区外侧及移行区的PI值差异。结果150例患者中，前列腺癌96例，前列腺增生54例。前列腺癌组病灶PI值大于前列腺增生组[（9．88±3．76）dB对（8．74±4．52）dB，P〈0．01]。前列腺周缘区内侧、周缘区外侧和移行区癌灶的PI值逐渐升高[（6．55±2．90）dB对（10．57±2．52）dB对（13．64±2．38）dB，P〈0．001]。前列腺癌PI值和部位的相关系数为0．718（P〈0．001）。以Gleason评分作为协变量，两者偏相关系数为0．720（P〈0．001）。结论不同部位前列腺癌的增强强度存在差异，明确不同部位前列腺癌增强程度的差异有助于进一步提高超声造影对前列腺癌的诊断敏感性及特异性。
Objective To analyze the enhancement degree of prostate cancer on contrast-enhanced transrectal ultrasonography （CETRUS） in relation to tumor location. Methods 150 patients suspected of prostate cancer were evaluated with CETRUS. The degree of enhancement of the lesions was objectively measured using peak intensity （PI） with time-intensity curve analysis software. The peak intensity of the lesions located in the medial peripheral zone, the lateral peripheral zone and the transition zone was compared and analyzed. Results Prostate cancer was detected in 96 of 150 patients. The mean PI value of the prostate cancer was significantly higher than that of the benign prostate hyperplasia lesions [（9.88±3.76） dB vs （8.74 ± 4.52）dB, P〈0.01]. The PI value of the cancer loci located in the medial peripheral zone, the lateral peripheral zone and the transition zone increased gradually [（6.55 ± 2.90）dB vs （10.57 ± 2.52）dB vs （13.64 ± 2.38）dB, P〈0. 001]. The Spearman correlation coefficient between the tumor location and the PI value was 0. 718 （ P〈0. 001）. The partial correlation coefficient was 0. 720 when the Gleason score was used as a covariate （ P 〈 0. 001）. Conclusions There was significant difference in enhancement degree between prostate cancer lesions with different location. Being aware of this might be valuable for improving the sensitivity and specificity of CEUS in diagnosis of the prostate cancer.
出处
《中华超声影像学杂志》
CSCD
北大核心
2012年第11期977-981,共5页
Chinese Journal of Ultrasonography
基金
上海市科委医学重点项目（10411952000）
上海市科委面上项目（09411963800）
上海交通大学医工交叉研究基金项目（YG2011MS43）
上海交通大学医学院科技基金项目（11XJ21019）
关键词
超声检查
微气泡
前列腺肿瘤
Ultrasonography
Microbubbles
Prostatic neoplasms
