摘要
目的探讨经直肠超声造影时间-强度曲线（TIC）定量参数在前列腺实性结节定性诊断中的应用价值。方法分析经穿刺或手术病理证实的43例前列腺疾病患者共55个实性结节的超声造影（CEUS）感兴趣区（ROI）的TIC定量参数，包括：始增时间（AT）、上升时间（RT）、达峰时间（TTP）、峰值减半时间（T1/2）、基础强度（BI）、增强强度（EI）、峰值强度（PI）、曲线上升支斜率B、曲线下降支斜率α，比较前列腺良恶性实性结节上述参数的差异。结果病理证实55个实性结节中恶性33个（恶性组）、良性22个（良性组）。恶性组AT、RT、TTP、T1／2短于良性组，α高于良性组，差异均有统计学意义（P〈0．05）；以AT〈11．22s、RT〈14．70s、TTP〈26．14s、T1/2〈74．61s、α〉0．29dB／s时诊断前列腺恶性结节的灵敏度分别为95．5％、59．1％、63．6％、90．9％、57．6％，特异度分别为48．5％、90．9％、78．8％、60．6％、95．5％。良恶性组间BI、EI、PI及B比较差异无统计学意义（P〉0．05）。结论经直肠超声造影TIC曲线定量参数分析有助于提高超声对前列腺实性结节的定性诊断能力，具有较高的临床应用价值。
Objective To investigate the application value of diagnosing prostate solid nodules using contrast - enhanced trans - rectal uhrasonography by analyzing the quantitative parameters of time - intensity curve （TIC）. Methods The TIC of selected region of interest （ROI） were analyzed by contrast - enhanced trans - rectal uhrasonography （ CE- TRUS） of total of 55 solid nodules in 43 patients with prostate disease confirmed with puncturing or pathology. The rele- vant quantitative parameters were recorded at the same time, including arrival time （AT）, rise time （RT）, time to peak （TIP）, time of half bubble wash out （T1/2 ）, baseline intensity （ BI）, enhanced intensity （ EI）, peak intensity （ PI）, the slope rate of ascending curve （ 13）, and the slope rate of descending curve （a）. The results were compared by statistical analysis. Results With the pathological results as the gold standard, 55 prostate solid nodules were divided into malignant group （33 nodules） and benign group （22 nodules）. AT, RT, TIP, and T1/2 of malignant nodules were shorter than those of benign nodules （P 〈 0.05 ） and α was higher than that of benign nodules （P 〈 0.05）. In the duration （ AT 〈 11.22 s, RT 〈 14.70 s, TIP 〈 26.14 s, T1/2 〈 74.61 s, α 〉 0.29 dB/s） the sensitivity of the diagnosis of prostate cancer were 95.5%, 59.1%, 63.6% , 90.9% and 57.6% respectively. The specificity were 48.5% , 90.9%, 78.8%, 60.6% and 95.5%, respectively. There was no significant difference in BI, EI, PI, and 13 between the two groups （P 〉 0.05）. Conclusion It has high clinical application value to analyze the quantitative parameters of TIC that can help to improve the ability of uhrasonography in the diagnosis of prostate nodules.
出处
《徐州医学院学报》
CAS
2014年第10期706-709,共4页
Acta Academiae Medicinae Xuzhou
基金
徐州医学院课题（53611224）
关键词
经直肠超声造影
前列腺
实性结节
时间-强度曲线
contrast - enhanced trans - rectal uhrasonography
prostate
solid nodules
time - intensity curve
