摘要
目的:探讨清脑降压片治疗高血压(肝阳上亢证)的临床疗效及对血管内皮功能的影响。方法:156例高血压患者随机分为治疗组79例和对照组77例。Ⅰ级高血压仅采用清脑降压片治疗,Ⅱ级高血压原有治疗不变加用清脑降压片,对照组采用安慰剂治疗,均口服,4～6片/次,3次/d。疗程4周。观察两组血压、肝阳上亢证,检测一氧化氮(NO)、内皮素(ET-1)。结果:清脑降压片能明显降低Ⅰ级、Ⅱ级高血压患者的收缩压(SBP)和舒张压(DBP)(P<0.01);清脑降压片能明显改善患者的肝阳上亢证证候积分,其疾病有效率和证候有效率分别达84.81%,89.87%(P<0.01);清脑降压片能升高NO水平,降低ET-1水平,调节NO/ET-1比值(P<0.01)。结论:清脑降压片对Ⅰ,Ⅱ级高血压患者均有明显的降压作用,能改善临床症状,其作用机制可能是通过调节NO/ET-1来实现的。
Objective： To investigate the clinical efficacy and impact of Qingnao Jiangya tablets （QJT） on endothelial function in the treatment of liver yang hypertension. Method： One hundred and fifty-six patients with hypertension were randomly divided into treatment group of 79 cases and control group of 77 cases. Grade I hypertension was treated with QJT; Grade 11 hypertension was additionally treated by QJT based on the original treatment, The controls were only received placebo. QJT was orally given 4-6 tablets tid for 4 weeks. Blood pressure, liver yang score, nitric oxide （NO） and endothelin （ET-1） were evaluated for the two groups. Result： QJT significantly reduced systolic blood pressure （SBP） and diastolic blood pressure （DBP） for the grade I and grade II hypertension patients （P 〈 0.01）. QJT significantly improved the patient＇ s liver yang scores, and the disease efficiency and syndromes efficiencies were 84. 81%, 89.87% （P 〈 0.01 ）. QJT increased NO level, reduced ET-1 level and adjusted NO/ET-1 ratio （P 〈 0.01 ）. Conclusion： QJT had obvious antihypertensive effect for grade I and grade II hypertensive patients. It could improve clinical symptoms, anu .us mechanism may be achieved by adjusting the ratio of NO/ET-1.
出处
《中国实验方剂学杂志》
CAS
北大核心
2012年第24期327-330,共4页
Chinese Journal of Experimental Traditional Medical Formulae
关键词
高血压
肝阳上亢证
清脑降压片
血管内皮
hypertension
liver yang ascending Syndrome
Qingnao Jiangya tablets
vascular endothelium
