摘要
目的观察百令胶囊联合厄贝沙坦对同种异体肾移植手术后患者蛋白尿的治疗效果。方法同种异体肾移植手术后患者56例,分为对照组26例,治疗组30例。对照组单用厄贝沙坦150 mg,qd,po;治疗组在对照组基础上加用百令胶囊1.0 g,tid,po。6个月后检查24 h尿蛋白定量、血常规、尿常规、肾功能、移植肾彩色B超。结果治疗组和对照组有效率分别为93.3%,84.6%(P<0.05)。6个月后,两组24 h尿蛋白定量均较治疗前明显下降(P<0.05),但治疗组下降更显著(P<0.05)。未观察到明显不良反应。结论百令胶囊联合厄贝沙坦能有效减少肾移植手术后患者的蛋白尿,效果优于单用厄贝沙坦,未见明显不良反应。
Objective To observe the effect of bailing capsule in combination with irbesartan on treating patients with proteinuria after renal transplantation. Methods A total of 56 patients were randomized into 2 groups ： control group （ n = 26） and treatment group （n = 30 ）. In the control group, the patients were treated with irhesartan 150 mg daily;the patients in the treatment group were administered with bailing capsule 1.0 g, three times a day. Six months later, amount of 24 h proteinuria, blood routine, urine routine and renal function （blood urine nitrogen, ereatinine） were detected, and the ultrasonography examination of the renal allograft was carried out. The side effects of the drugs were documented. Results In the control group ,the total effective rate of the control group and the treatment group was 84.6% and 93.3% ,respectively （P〈0.05）. After 6 months, the amounts of 24 h proteinuria in both groups were decreased significantly （P〈0.05） ;the amount of 24 h proteinuria was decreased more significantly in the treatment group than in the control group （P〈0.05）. No apparent side effect was observed. Conclusion Bailing capsule in combination with irhesartan could reduce the proteinuria of patients with renal allograft, with better result than single use of irbesartan, without significant side effect.
出处
《医药导报》
CAS
北大核心
2012年第12期1567-1569,共3页
Herald of Medicine
关键词
百令胶囊
厄贝沙坦
同种异体
肾移植
蛋白尿
Bailing capsule
Irbesartan
Allograft
Renal transplantation
Proteinuria
