摘要
细胞外调节蛋白激酶（extracellular regulated protein kinases,ERK）通路是20世纪80年代初发现的丝裂原活化蛋白激酶（mitogen-activatedprotein kinase,MAPK）家族中的一个重要成员,由Raf、MEK（MAPK/ERK kinase）、ERK三个不同层级的激酶蛋白组成,并依次顺序激活。
Virus utilizes components of the host cell′s metabolic machinery for its reproduction.Activation of the extra-cellular regulated protein kinases（ERK）signaling cascade has been shown to be one of the important machineries in response to infections of a variety of viruses.Therefore,blockage of this cellular pathway may finally bring completely novel concepts of antiviral therapy.In this review,the critical role and important impact of ERK pathway in viral infection,e.g.viral replication and its pathogenesis were summarized;and the current progress in cancer therapy and the potential application of small molecular inhibitors specific to Raf-MEK-ERK signaling were discussed as well.
出处
《中国病毒病杂志》
CAS
2012年第6期404-408,共5页
Chinese Journal of Viral Diseases
基金
国家高技术研究发展计划(863计划)资助项目(2007AA02Z317)
国家自然科学基金(30470084
21172012/B020601)
