摘要
目的 研究 2型糖尿病患者的骨矿含量及其与病程、糖代谢控制程度和相关骨生化指标的关系。方法 6 6例分为三组。A组 2 0例 ,发病 2年以下。B组 2 6例 ,发病 8年以上。其中 B1 组 9例 ,空腹血糖 <7.8mm ol· L- 1 ;B2组 1 7例 ,空腹血糖 >7.8mmol· L- 1 。C组 2 0例 ,为正常对照组。6 6例均行腰椎 QCT,测定空腹血糖、血清钙、血清磷、ICTP及 BGP。结果 A组与 C组骨矿含量无显著差异 ;B组比 A、C组显著降低。 B2 组较 C组显著降低 ;B1 组与 C组、B2 组比较无显著差异。 ICTP与 BGP在三组间比较差异均无显著性。骨矿含量与 BGP和 ICTP无显著相关性。结论 初发病的男性患者骨矿含量并不降低 ;发病 8年以上的男性患者骨矿含量显著降低 ;
Objective To clarify the questions whether bone mineral contents(BMC) in patients with NIDDM decreases or not; snd is there any correlation between BMC and the duration of NIDDM, sugar level and bone biochemical markers?Methods A total of 66 subjects were divided into three groups.: Group A, 20 patients with DM no longer than 2 years; Group B subdividing into B1, 9 patients with FBG<7.8 mmol/L and Group B 2,17 patients with FBG>7.8 mmol/L;Group C,20 healthy subjects.BMC by quantitative computed tomography(QCT),laboratory tests of FBG,Ca 2+ ,P 3+ ,ICTP and BGP were performed in all 66 subjects.Results BMC of Group B was significantly lower than that of Group A and Group C.BMCof subgroup B 2 was significantly lower than that of Group C. No correlation was found between BMC and ICTP or BGP.Conclusion BMC in patients with a duration less than 2 years was normal, while in patients longer than 8 years was significantly decreased. BMC has no correlation with ICTP and BGP.
关键词
骨矿含量
定量CT
Ⅱ型糖尿病
诊断
bone mineral content
quantitative computed tomography(QCT)
non insulin dependent diabetes mellitus (NIDDM)
ICTP
BGP
