摘要
目的：研究非绝经期女性糖尿病患者骨密度的影响因素。方法：女性非绝经期2型糖尿病患者73例,根据腰椎1-4的骨密度分为骨质疏松组、骨量减少组和骨量正常组,采用全自动生化测定仪测定3组空腹血糖及血清钙、磷和碱性磷酸酶水平,采用放射免疫法测定血浆C肽水平,采用化学法测定糖化血红蛋白（HbA1c）,并对3组进行比较。结果：（1）3组的年龄、HbA1c及血清磷、空腹血糖水平差异无统计学意义（P〉0.05）,骨质疏松组、骨量减少组糖尿病病程明显长于骨量正常组（t分别为1.93、1.37,P〈0.05）,空腹C肽水平均明显低于骨量正常组（t分别为3.41、3.07,P〈0.01）,骨质疏松组体重指数明显低于骨量正常组（t=5.04,P〈0.01）,3组血钙水平均低于正常参考值下限[（2.16±0.37）mmol/L],骨质疏松组明显低于骨量正常组（t=2.83,P〈0.05）,3组血清碱性磷酸酶水平均在正常参考值范围内,但骨质疏松组和骨量减少组均明显高于骨量正常组（t松=3.69,P〈0.01;t少=2.11,P〈0.05）。（2）影响2型糖尿病患者骨密度的多因素分析显示糖尿病患者骨质疏松相关因素是空腹C肽及血清钙、碱性磷酸酶水平。结论：（1）糖尿病患者血清钙水平较正常标准低。（2）糖尿病患者应积极控制血糖,避免因糖代谢不佳导致的体重下降和对胰岛β细胞的毒性作用,尽量保护β细胞功能,以延缓或减轻糖尿病合并骨质疏松症。（3）血清碱性磷酸酶水平升高是骨质疏松症的危险因素,该指标有助于及早诊治糖尿病合并的骨量减少和骨质疏松症。
Objective： To study the risk factor of bone density in non-menopausal diabetic mellitus female patients. Methods： Seventy-three non-menopausal female patients with T2DM were divided into 3 groups; osteoporosis group, osteopenia group and normal group according lumbar vertebrae 1-4 bone dens!t0metry. Serum glucose, calcium, phosphours, alkaline phosphatase were determined using total automatic biochemistry determinator, serum C-peptide were determined using radio-immunity method, GHbAlc was determined using chemical method, comparing with all data above in three groups. Results： （1） There were no statistically significant differences on age, HbAlc, serum phosphours and serum glucose in three groups （P 〉0.05） ,osteoporosis group and osteopenia group DM Course length was longer than that in,normal group （t = 1.93, 1.37,P 〈0.05）, the fast C group （t = 3.41,3.07,P 〈0.01）,BMI in osteoporo 0.01）, serum calcium level was lower than that pe sis ptid level was obviously lower than that in normal group was lower than nomal group （t = 5.04,P 〈 in normal reference limit （2.16!0.37 mmol/L）, osteoporosis group serum calcium was lower than normal group significantly （t = 2.83, P d0.05）, it had statis- tics difference. （2）The correlation factors of osteoporosis in diabetes patients were fast C peptid level, serum calcium and serum alkaline phosphatase. Conclusion： （1）Diabetic mellitus blood calcium level in DM is lower than normal standard. （2） In diabetic mellitus case, their blood suger should be controlled positively to avoid hyperglycemic leading to body weight descent and toxic action to β cell, as far as possible to protect 13 cell function, to postpone or stop osteoporosis . （3）This study find the increase of blood alkaline phosphatase is the osteoporosis＇ risk factor, use this marker can easily help find the diabetes with osteoporosis earlier.
出处
《新疆医科大学学报》
CAS
2007年第8期837-839,共3页
Journal of Xinjiang Medical University
关键词
非绝经期女性糖尿病
钙
骨密度
non-menopausal females diabetic mellitus
calcium
bony density
