摘要
为更新、更深刻及更全面认识T细胞超抗原(T-SAg)。本文查阅大量相关资料,并结合有关临床病例。对T-SAg特点、生物效应、发病机制及治疗走向重新作了全面综合性分析,其中加入了许多新观点,尤其是对T-SAg扰乱Th1/Th2平衡、CD28是超抗原产生效应的必须受体、嵌合超抗原受体可抑制其效应、修饰树突状细胞、免疫佐剂为SAgT细胞提供新表位等作详细阐述。这些为进一步研究与探讨T-SAg将起到重要作用。
In order to gain a newer, deeper and more comprehensive understanding of the T-SAg, this paper, consulting a large number of relevant materials and combined with abundant related clinical cases, analyses the character is this of T- SAg, its biological effects, the pathogenesis as well as the tendency of its treatment in a comprehensive and synthetic way. A lot of fresh ideas one introduced in this paper, especially detailed explanations one given to the disrupted balance of the Thl/Th2 by T-ASg, CD28, which is the necessary receptor when the super antigen takes effect, the restrained effect that appears is the super antigen is ehimerizmed with its receptor, the super antigen＇s ability to modify dendritic cells, and the epi-position of SAgT cells provided by the immune edjuvants for SAgT cells. These play an important role for further re- search and discussion on T-SAg.
出处
《中国现代医生》
2012年第32期27-29,共3页
China Modern Doctor
