摘要
目的探讨维生素D3对2型糖尿病(T2DM)患者糖代谢和体内相关炎症因子水平的影响。方法选择无急性并发症的T2DM患者85例。按性别、年龄因素随机分为基础治疗组(对照组)和基础治疗加维生素D3组(维生素D组)。对照组采用基础药物将空腹血糖(FPG)控制在7.0 mmol/L以下,将餐后2 h血糖(2 hPG)控制在10.0 mmol/L以下。维生素D组在对照组基础上口服维生素D31 000 IU/d。疗程12周。在疗程结束后的次日取空腹血清,ELISA法测定血清中炎症因子白介素-6(IL-6)和肿瘤坏死因子-α(TNF-α)水平。同时测定FPG、2 hPG、超敏C反应蛋白(hs-CRP)和糖化血红蛋白(HbA1c)。结果经过12周的治疗,维生素D组患者的FPG、2 hPG和HbA1c值与对照组比较,差异均无统计学意义(均P>0.05);但维生素D组患者体内的hs-CRP、TNF-α和IL-6水平均明显低于对照组(均P<0.05)。结论维生素D3降低了T2DM患者体内的炎症状态。
Objective To explore effects of vitamin D3 supplementation on inflammation in patients with type 2 diabetes mellitus（T2DM）.Methods In according with selected criteria,85 patients with T2DM were randomly divided into the control and vitamin D groups.Patients of both groups were treated with basic medicine to control the blood glucose level and the patients in vitamin D group were orally administered vitamin D3 1 000 IU daily in addition.High-sensitivity C-reactive protein（hs-CRP）,tumor necrosis factor-α（TNF-α）,interleukin-6（IL-6）,fasting plasma glucose（FPG）,2 h-postprandial plasma glucose（2 hPG）,and hemoglobin A1c（HbA1c） were assessed after the 12-week intervention.Results There was no significant difference in the level of FPG,2 hPG and HbA1c between two groups after treatment（all P0.05）.However,the level of TNF-α,IL-6 and hs-CRP in the vitamin D group was significantly lower than that in the control group（all P0.05）.Conclusion Vitamin D supplementation for 12 weeks has improved inflammation significantly in T2DM.
出处
《苏州大学学报（医学版）》
CAS
2012年第5期671-673,共3页
Suzhou University Journal of Medical Science
基金
国家自然科学基金资助项目(81072286)
江苏省自然科学基金资助项目(SBK201221995)
关键词
维生素D
2型糖尿病
炎性因子
vitamin D
type 2 diabetes mellitus
inflammatory biomarker
