摘要
目的 探讨神经细胞粘附分子 (NCAM )在胆管癌神经浸润中的作用。方法 78例胆管癌标本切片HE染色 ,观察记数小血管、小淋巴管、神经纤维浸润数。用抗人NCAM单抗行链霉亲和素 过氧化物酶 (S P)法染色 ,观察肿瘤细胞的阳性情况。结果 肿瘤细胞神经浸润阳性与小血管、小淋巴管的浸润呈正相关 (P <0 .0 1) ;肿瘤细胞NCAM表达阳性 (5 1例 )与神经浸润阳性 (6 8例 )呈正相关 (P <0 .0 1) ;肿瘤的恶性程度与NCAM表达呈正相关 ;NCAM表达与小血管、小淋巴管浸润无关。结论 NCAM可能是胆管癌的特征分子之一。它可引导胆管癌细胞向神经纤维趋化和粘附 ,即起“导航”和“停泊”作用。
Objective To elucidate the role of the expression of neural cell adhesion molecule (NCAM) in the development of perineural invasion in cholangiocarcinoma. Methods The histopathologic and immunohistochemical(S P) studies were performed on 78 patients with cholangiocarcinoma. The overall incidence of NCAM expression, perineural, lymphatic and vascular vessel invasion were counted to investigate the relationship among them. Results Perineural invasion was positively correlated with lymphatic and vascular vessel invasion(P<0.01). A positive correlation was found between the perineural invasion(68 cases) and tumor NCAM expression(51 cases). A definite correlation was also found between cancer differentiation and NCAM expression. Conclusion NCAM is one of the most important molecules and may play a role as a “navigating” and “docking” molecule in the development of perineural invasion.
出处
《中华实验外科杂志》
CAS
CSCD
北大核心
2000年第2期171-172,共2页
Chinese Journal of Experimental Surgery
关键词
胆管癌
神经浸润
NCAM
Cholangiocarcinoma
Perineural invasion
Neural cell adhesion molecule
