摘要
目的探讨硝苯地平缓释剂（SR）与硝苯地平控释剂（GITS）治疗原发性高血压的临床疗效。方法将160例原发性高血压2级患者随机分为SR组和GITS组。SR组给予硝苯地平缓释片20mg，2次／d；GITS组给予硝苯地平控释片30mg，1次／d。两组均治疗8周，并对所有患者进行动态血压监测（ABPM），观察治疗前后两组患者的24h平均血压、心率、谷／峰（T／P）值的变化及不良反应等情况。结果治疗后GITS组收缩压（SBP）、舒张压（DBP）的T／P比值分别为68．5％、74．6％，均高于SR组的57．2％、61．1％（X2=6．32、7．05，均P〈0．05）；GITS组心率低于SR组（t=4．17，P〈0．05）；两组不良反应差异无统计学意义（X2=0．16，P〉0．05）。结论SR与GITS均能有效降压，但GITS更高效、平稳、安全，对心率的影响小。
Objective To investigate the clinical efficacy of nifedipine sustained-release formulation （SR） and nifedipine controlled-release（GITS） in the treatment of essential hypertension. Methods 160 patients with es- sential hypertension were randomly divided into two groups. The SR group was treated with SR 20 mg twice a day; GITS group was treated with GITS 30 mg once a day. All patients were given ambulatory blood pressure monitoring （ABPM） and observed the 24-hour average blood pressure, heart rate, changes in the trough/peak （T/P） values, and adverse reactions before and after treatment in two groups. Results The T/P value of systolic blood pressure（SBP） and diastolic（DBP） in the GITS group was 68.5% ,74.6% , respectively, which were higher than those of SR group （57. 2% ,61.1% ） （ X2 = 6.32,7.05, all P 〈 0.05 ） ;GITS group was significantly lower than the SR group in heart rate （t = 4.17, P 〈 0.05 ） ;Adverse reactions between two groups had no significant difference （X2 = 0.16, P 〉 0.05 ）. Conclnsion SR and GITS can effectively lower blood pressure, but GITS is more efficient, stable, safe, small impact on the heart rate.
出处
《中国基层医药》
CAS
2012年第23期3558-3559,共2页
Chinese Journal of Primary Medicine and Pharmacy
关键词
硝苯地平
剂型
高血压
疗效
Nifedipine
Formulations
Hypertension
Efficacy
