摘要
目的研究自发性高血压大鼠（ＳＨＲ）动脉血压变异性（ＢＰＶ）和压力反射敏感性（ＢＲＳ）的改变及二者间相关性。方法清醒、自由活动状态下测定ＳＨＲ及对照ＷＫＹ大鼠２４小时收缩压（ＳＢＰ）、舒张压（ＤＢＰ）、心率（ＨＲ）及其各自变异性的改变；单次静脉注射去氧肾上腺素（５μｇ／ｋｇ）以测定压力反射对心率的控制功能（ＢＲＳＨＲ）；化学切除自主神经阻断压力反射传出通路后，比较静注去氧肾上腺素后的升压曲线下面积差异，测定压力反射对血压的控制功能（ＢＲＳＢＰ）。结果ＳＨＲ的血压及血压变异性显著高于ＷＫＹ大鼠，ＢＲＳ明显降低；ＢＲＳ与ＳＨＲ和ＷＫＹ大鼠的ＢＰＶ呈负相关，其中ＢＲＳＢＰ与ＢＰＶ的相关系数高于ＢＲＳＨＲ与ＢＰＶ的相关系数；ＢＲＳＨＲ或ＢＲＳＢＰ与心率及心率变异性间均无相关性。结论压力反射敏感性与血压变异性间呈负相关关系，其中ＢＲＳＢＰ为反映压力反射功能的较敏感指标。
Objective To determine baroreflex function of spontaneously hypertensive rats (SHR) and WKY rats, and investigate the relationship between baroreflex sensitivities (BRS) and arterial blood pressure variability (BPV). Methods Twenty four hour arterial blood pressure (SBP and DBP), heart rate and their variabilities were measured in conscious, unrestrained SHR and WKT rats. BRS of heart rate control (BRS HR ) was measured by using a bolus intravenous injection of phenylephrine (5 μg/kg). BRS of blood pressure control (BRS BP ) was measured by comparing the pressor responses to phenylephrine before and after the blockade of baroreflex efferent pathway. Results SHR had significantly higher blood pressure and BPV than WKY rats. A significant inverse correlation was found between BRS BP and BPV in SHR and WKT rats. BRS HR seemed weakly related to BPV when compared with BRS BP in the two strains of rats. Conclusion Baroreflex function in SHR was impaired, while BPV increased markedly. A significant inverse correlation existed between BRS and BPV in the two strains of rats. BRS BP might be a more sensitive index of the baroreflex function in the rats.
出处
《中华心血管病杂志》
CAS
CSCD
北大核心
1998年第5期346-349,共4页
Chinese Journal of Cardiology
关键词
压力反射
高血压
血压变异性
baroreceptor reflex hypertension blood pressure variability rats
