老年高血压患者降压治疗后舒张压对心脑血管事件的影响被引量：21

Effect of diastolic blood pressure on cardio-cerebral vascular events in elderly hypertensive patients after antihypertensive treatment

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摘要目的探讨老年高血压患者降压治疗后,舒张压水平与心脑血管事件的关系,并了解是否存在关于舒张压的"J"型曲线。方法采用回顾性研究方法将1010例老年高血压患者按降压治疗后舒张压水平分为6组:1组舒张压<65 mm Hg(1 mm Hg=0.1 33 kPa)68例,2组舒张压65～69 mm Hg 154例,3组舒张压70～74 mm Hg 334例,4组舒张压75～79 mm Hg 235例,5组舒张压80～84 mm Hg 148例,6组舒张压85～89 mm Hg 71例;应用Cox比例风险模型分析不同舒张压水平对心脑血管事件的影响。结果 2组心脑血管事件发病率最低,在校正传统危险因素后,与2组比较,4组、5组和6组心脑血管事件发生相对风险分别增加了68%、184%及203%(P<0.05,P<0.01),1组心脑血管事件发生相对风险虽有增加趋势,但差异无统计学意义(P>0.05)。结论老年高血压患者心脑血管事件随降压治疗后舒张压降低有减少趋势,舒张压降至65～69 mm Hg亦能获益。 Objective To study the relation between diastolic blood pressure（DBP） and cardio-cere- bral vascular events in elderly hypertensive patients and to observe whether there is a＂J-shaped curve＇for diastolic pressure. Methods One thousand and ten elderly hypertensive patients were divided into〈65 mm Hg（1 mm Hg=0. 133 kPa）group（group 1,n=68）,65--69 mm Hg group （group 2,n=154）,70--74 mm Hg group（group 3,n=334）,75--79 mm Hg group（group 4,n= 235）,80--84 mm Hg group（group 5,n=148）,and 85--89 mm Hg group（group 6,n=71）accord- ing to their DBP after antihypertensive treatment. Effect of DBP on cardio-cerebral vascular events was analyzed using the Cox proportional risk model. Results The incidence of cardio-eere- bral vascular events was 68%, 184%, 203% in groups 4--6, which was higher than that in group 2 after the adjustment of traditional risk factors（P〈0.05 ,P〈0.01）. No significant difference was found in the incidence of cardio-cerebral vascular events between group 1 and other groups, al- though it tended to increase in group 1. Conclusion Cardio-cerebral vascular events tend to de- crease when the DBP decreases to 65--69 mm Hg after antihypertensive treatment.

作者王海军司全金邹晓徐昆

机构地区解放军总医院心血管一科

出处《中华老年心脑血管病杂志》 CAS 北大核心 2012年第7期683-686,共4页 Chinese Journal of Geriatric Heart,Brain and Vessel Diseases

关键词高血压血压测定降压控制性心血管疾病冠心病脑梗死抗高血压药 hypertension blood pressure determination hypotension, controlled cardiovasculardiseases coronary disease brain infarction antihypertensive agents

分类号 R544.1 [医药卫生—心血管疾病]

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