摘要
目的探讨心源性脑卒中与血浆脑钠肽（BNP）的关系。方法收集81例急性脑卒中患者临床资料，按照TOAST分型，分为非心源性脑卒中，包括大动脉粥样硬化性、心源性、腔隙性、其他原因及原因不明脑卒中。入院24h内采集血样标本，采用ELISA方法测定血脑钠肽水平。比较心源性与非心源性脑卒中患者的血脑钠肽水平。结果心源性脑卒中患者的血浆BNP水平为（147．5±7．8）ng／L，动脉粥样硬化性卒中患者为（51．2±5．8）ng／L，腔隙性卒中患者为（39．5±10．0）ng／L。心源性脑卒中患者的血浆BNP水平显著高于非心源性脑卒中患者（t=67．8，23．6，17．6，均P〈0．01）。结论血浆BNP水平可用于鉴别心源性与非心源性脑卒中，其在脑卒中的病因学诊断中可能具有一定的临床意义。
Objective To study the relationship between cardioembolic stroke and plasma BNP by analyzing the plasma BNP level in cardioembolie stroke patients. Methods The clinical data of 81 patients with acute stroke were collected. According to the TOAST classification, all the patients were diagnosed as non-cardioembolic stroke,including atherothrombotic,lacunar, others etiology and undetermined etiology eardioembolic stroke. Blood samples were drawn on emergency department arrival（within 24 hours） to test BNP（ assayed by ELISA）. The plasma BNP level be- tween non-eardioembolic stroke and eardioembolic stroke was compared. Results Cardiogenic stroke patients with plasma BNP level （ 147.5 ± 7.8） ng/L, atherosclerotic stroke patients level （51.2 ±5.8 ） ng/L, lacunar stroke （ 39.5 ±10.0）ng/L. Higher levels of BNP were observed in patients with cardioembolie stroke than other stroke subtypes（ t = 67.8,23.6,17.6, all P 〈 0.01 ）. Conclusion The plasma BNP could be used for distinguishing cardioembolic stroke from other stroke subtypes and has great clinical significance in etiologic diagnosis of ischemie stroke subtypes.
出处
《中国基层医药》
CAS
2012年第4期493-494,共2页
Chinese Journal of Primary Medicine and Pharmacy
关键词
心源性
脑
卒中
脑钠肽
Cardioembolic stroke
Bain natriuretic peptide
