摘要
人食管癌相关基因4（ECRG4）通过与核转录因子-KB（NF—KB）与p53相互作用参与调节细胞周期从而发挥抑癌基因的功能。研究表明ECRG4表达下调与多种肿瘤的发生发展密切相关，提示ECRG4有望成为针对恶性肿瘤的潜在分子诊断标志物和治疗靶点。
Esophageal cancer related gene 4 （ECRG4） serves as a tumor suppressor gene through interacting with NF-KB and p53 pathways. Multiple studies have demonstrated that the down-regulated expression of ECRG4 occurs in a variety of cancer types, indicating a potential application of ECRG4 as a molecular diagnostic marker as well as a therapeutic target
出处
《国际肿瘤学杂志》
CAS
2012年第11期806-808,共3页
Journal of International Oncology
基金
基金项目：广东省医学科研基金资助项目（B2012261）
关键词
基因
肿瘤抑制
肿瘤
肿瘤标记
生物学
诊断
Genes, tumor suppressor
Neoplasms
Tumor markers, biological
Diagnosis
