摘要
目的评价地西泮对高热惊厥再发患儿的预防作用及安全性。方法选择2010年10月～2011年6月收治的高热惊厥再发患儿94例作为研究对象,随机分为对照组46例和观察组48例,对照组采取常规治疗措施,观察组加用地西泮口服预防再发,比较两组患儿的临床疗效及不良反应发生情况。结果观察组的发热及惊厥复发率明显低于对照组,组间差异有统计学意义[18.8%(9/48)比37.0%(17/46),10.4%(5/48)比30.4%(14/46),均P<0.05];观察组的发热及惊厥次数均明显少于对照组,组间差异均有统计学意义([8.6±2.5)次比(12.4±3.1)次,(4.3±1.1)次比(6.7±1.6)次,均P<0.05];两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论地西泮对高热惊厥再发患儿的预防作用良好,并且安全、可靠,是临床首选的用药方案之一。
Objective To evaluate the preventive effect and safety of diazepam in febrile seizures recurrence in children.Methods 94 cases of children from October 2010 to June 2011 with febrile seizures recurrence in our hospital were chosen as the research object. They were randomLy divided into the control group of 46 cases and the observation group of 48 cases. The control group was taken with conventional treatment measures, and the observation group was taken with diazepam for the prevention of recurrence. The clinical efficacy and adverse reactions for the two groups of children were compared. Results The recurrence rate of fever and convulsions of the observation group was significantly less than the control group, the differences between the two groups were statistically significant [18.8%（9/48）vs 37.0%（17/46）, 10.4%（5/48）vs 30.4%（14/46） ,all P〈 0.05]. The number of fever and convulsions in the observation group was significantly less than the control group, the difference between the two groups was statistically significant [（8.6±2.5）times vs（12.4±3.1 ）times, （4.3±1.1）times vs （6.7±1.6）times,all P〈0.05]. The rates of adverse events for the two groups were compared, and there was no significant difference （P〉0.05）. Conclusion The preventive effect of diazepam for the recurrence of febrile seizures in children is reliable and safe, is one of the clinical preferred medication programs.
出处
《当代医学》
2012年第32期100-101,共2页
Contemporary Medicine
关键词
高热惊厥
地西泮
预防
安全性
Febrile convulsions
Diazepam
Prevention
Secttrity
