摘要
脱嘌呤脱嘧啶核酸内切酶1又称氧化还原因子-1,是一种双功能酶,不仅具有核酸内切酶活性,发挥DNA修复功能,而且具有氧化还原功能,调控多种重要转录因子的活性。目前研究发现APE1/Ref-1在人体多种肿瘤中表达且与肿瘤的发生、发展及预后相关。APE1/Ref-1可能成为极具潜力的肿瘤基因治疗的新靶点。本文就APE1/Ref-1的结构、功能及在肿瘤研究方面的进展作了一系列的回顾与总结。
Apurinic/apyrimidinic endonuclease 1 also known as redox factor-1,is a bifunctional enzyme,which not only has the endonuclease activity,playing DNA repair function but also has a redox function,regulating a variety of important transcription factor activity.At present,studies have found that APE1/ Ref-1 is expressed in a variety of human tumors and relates to tumor occurrence,development and prognosis.APE1 / Ref-1 may be a potential novel target for gene therapy of cancer.This article tries to make a series of review and summary on the APE1/ Ref-1 structure,function and how it benefits tumor research progress.
出处
《现代肿瘤医学》
CAS
2012年第11期2426-2429,共4页
Journal of Modern Oncology
基金
国家自然科学基金(编号:81172460/M162)
