摘要
目的:探讨尿多酸肽注射液联合化疗治疗晚期复治非小细胞肺癌的近期疗效、不良反应以及对患者生活质量的影响。方法:经病理学或细胞学确诊的非小细胞肺癌患者67例,其中男性31例,女性36例,中位年龄59岁。尿多酸肽注射液300 ml与化疗联合给药,将尿多酸肽注射液与氯化钠注射液或5%葡萄糖注射液,按1∶1稀释后静脉滴注,滴速以原药100ml/小时为宜。于化疗前7天开始给药,化疗的当天停用本品,共2-3周期。结果:A组CR(0),PR(4),SD(17),总有效率为11.4%,肿瘤控制率为60.0%;临床受益率(CBR)为57.1%(21/35);B组CR(0),PR(2),SD(10),总有效率为6.3%,肿瘤控制率为37.5%(12/32)。A组中位生存时间9.3月,B组6.1月,1年生存率A组48.6%(17/35),B组31.3%(10/32),两组比较差异有统计学意义(P<0.05)。两组毒副反应主要为骨髓抑制、胃肠道反应,差异无统计学意义(P>0.05)。结论:尿多酸肽联合化疗治疗晚期复治非小细胞肺癌有一定的疗效,能明显改善晚期肺癌患者的生活质量,且不良反应轻,患者能够耐受,值得临床进一步研究。
Objective：To study the efficacy,toxicity and the life quality improvement of uroacitides combined with chemotherapy in the treatment for advanced retreated non-small cell lung cancer.Methods：All 67 advanced non-small cell lung were confirmed by histopathology or cytopathology.Divided into group A and group B（the treatment group 35 and the control group 32）.Both groups were given chemotherapy with NP /GP/TP regimen.Meanwhile group A received uroacitides combined with chemotherapy：Uroacitides was administed 300ml ivgtt,per day for 7 days prior to the chemotherapy,except the day receiving chemotherapy.The regimens were repeatedly treated every 3 weeks and evaluated the efficacy after 2 cycles.Results：The overall response rate was 11.4% in group A and 6.3% in group B（P〈0.05）.The median survival time was 9.3 months in group A and 6.1 months in group B.Tumor control rates of Aand B were 60.0% and 37.5%（P〈0.05）;The 1-year overall survival rate of A and B were 48.6% and 31.3%（P〈0.05）.Clinical benefit response（CBR）was 54.3%（19/35）.The main toxicities were myelosuppression,gastrointestinal reaction,and there was no significant difference in incidences of toxicities between the two groups（P〈0.05）.Conclusion：Uroacitides combined with chemotherapy for advanced retreated non-small cell lung cancer shows a good curative effect and low toxicity,and can also improve the patient＇s quality of life may significantly prolong.It is worth being studied further.
出处
《现代肿瘤医学》
CAS
2012年第11期2267-2269,共3页
Journal of Modern Oncology
基金
上海市闵行区自然科学基金资助项目(编号:2009MHZ025)
关键词
尿多酸肽
化疗
晚期复治非小细胞肺癌
uroacitides
chemotherapy
advanced retreated non-small cell lung
