期刊文献+

培美曲塞治疗老年晚期非小细胞肺癌护理 被引量:3

Observation and Nursing of Elderly Patients with Advanced Non-small Cell Lung Cancer under the Treatment with Pemetrexed
暂未订购
导出
摘要 目的:探讨培美曲塞治疗老年晚期非小细胞肺癌的观察和护理。方法:通过8例患者应用培美曲塞32次观察用药过程中的不良反应,采取护理对策。结果:1例第1次输注过程中出现寒战、发热,1例输注后出现骨髓抑制、消化道出血,经对症处理均顺利完成化疗。结论:培美曲塞应用时要掌握正确的给药方法,严格调整滴速,及时发现不良反应及时处理,将不良反应降至最低。 Objective:To discuss the observation and nursing of the patients with advanced non - small cell lung cancer in the course of the therapy with Pemetrexed. Methods : Observation of ill reactions in the course of medication was made among 8 patients with 32 times administration of pemetrexed and proper Counter - measures of nursing were herefrom taken. Results : One case presented fever, chill in the first time transfusion; One case manifested bone marrow depression and alimentary tract hemorrhage. Conclusions: The correct transfusion technique should be grasped to administrate pemetrexed, adjusting the transfusion rate according to the doctor $ advice, detecting and dealing with ill - reactions in time and reducing the effect of ill reaction at full steam.
出处 《包头医学院学报》 CAS 2008年第4期396-397,共2页 Journal of Baotou Medical College
关键词 培美曲塞 晚期非小细胞肺癌 护理 Pemetrexed Advanced NSCLC Nursing
  • 相关文献

参考文献5

  • 1陈治宇,许立功.抗肿瘤新药——培美曲塞[J].中国新药与临床杂志,2005,24(2):143-147. 被引量:58
  • 2Zinner RG, Fossella FV, Gladish GW, et al. Phase II study of pemetrexed in combination with carboplatin in the first - line treatment of advanced non - small cell lung cancer [ J ]. Cancer,2005,104 ( 11 ) :2449 - 2456.
  • 3Scagliotti GV. Pemetrexed:a new cytotoxic agent in the development for first - line non - small - cell lung cancer[ J]. Lung Cancer,2005,50 : 15 - 19.
  • 4Atkins JN, Jacobs SA, Wieand HS, et al. Pemetrexed/oxaliplatin for first - line treatment of patients with advanced colorectal cancer: a phase 1I trail of the National Surgical Adjuvant Breast and Bowel Project Foundation Research Program [ J ]. Clin Colorectal Cancer, 2005,5 ( 3 ) : 181 - 187.
  • 5Hanna N, Shepherd FA, Fossella FV, et al. Randomized Phase Ⅲ trial of pemetrexed versus docetaxel in patients with non - small - cell lung cancer previously treated with chemotherapy [ J]. J Clin Oncol,2004 ,2 (9) : 1589 - 1597.

二级参考文献22

  • 1[1]HANAUSKE AR,CHEN V,PAOLETTI P,et al.Pemetrexed disodium:a novel antifolate clinically active against multiple solid tumors [J].Oncologist,2001,6(4):363-373.
  • 2[2]ADJEI AA.Pemetrexed:a multitargeted antifolate agent with promising activity in solid tumors [J].Ann Oncol,2000,11(10):1335-1341.
  • 3[3]SCHULTZ RM,PATEL VF,WORZALLA JF,et al.Role of thymidylate synthase in the antitumor activity of the multitargeted antifolate,LY231514 [J].Anticancer Res,1999,19(1A):437-443.
  • 4[4]TEICHER BA,CHEN V,SHIH C,et al.Treatment regimens including the multitargeted antifolate LY231514 in human tumor xenografts.[J].Clin Cancer Res,2000,6(3):1016-1023.
  • 5[5]FOSSELLA FV,GATZEMEIER U.Phase I trials of pemetrexed [J].Semin Oncol,2002,29(2 Suppl 5):8-16.
  • 6[6]RINALDI DA,KUHN JG,BURRIS HA,et al.A phase I evaluation of multitargeted antifolate (MTA,LY231514),administered every 21 days,utilizing the modified continual reassessment method for dose escalation [J].Cancer Chemother Pharmacol,1999,44(5):372-380.
  • 7[7]THODTMANN R,DEPENBROCK H,DUMEZ,et al.Clinical and pharmacokinetic phase I study of multitargeted antifolate (LY231514) in combination with cisplatin [J].J Clin Oncol,1999,17(10):3009-3016.
  • 8[8]HUGHES A,CALVERT P,AZZABI A,et al.Phase I Clinical and Pharmacokinetic Study of Pemetrexed and Carboplatin in Patients With Malignant Pleural Mesothelioma [J].J Clin Oncol,2002,20(16):3533-3544.
  • 9[9]RUSTHOVEN JJ,EISENHAUER E,BUTTS C,et al.Targeted antifolate LY231514 as first-line chemotherapy for patients with advanced non-small-cell lung cancer:a phase II study.National Cancer Institute of Canada Clinical Trials Group [J].J Clin Oncol,1999 ,17(4):1194.
  • 10[10]CLARKE SJ,ABRATT R,GOEDHALS L,et al.Phase II trial of pemetrexed disodium (ALIMTA,LY231514) in chemotherapy-naive patients with advanced non-small-cell lung cancer [J].Ann Oncol,2002,13(5):737-741.

共引文献57

同被引文献19

引证文献3

二级引证文献8

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部