摘要
目的 探讨血管紧张素转化酶 (ACE)基因缺失多态性与中国人脑梗死、高血压性脑出血的关系。方法 应用聚合酶链反应 (PCR)方法 ,检测 5 8例脑梗死患者、31例高血压性脑出血患者以及 6 0名正常人的 ACE基因型。结果 高血压性脑出血组缺失纯合子 (DD)基因型频率为 2 6 % ,与正常对照组比较有显著性差异 (P<0 .0 5 ) ;脑梗死组 DD基因型频率为 2 1% ,与正常对照组比无显著性差异 (P>0 .0 5 ) ,但进一步分析表明 ,伴有高血压的脑梗死患者及女性脑梗死患者 DD基因型频率分别为 2 7%和 2 6 % ,与正常对照组比有显著性差异 (P<0 .0 5 )。结论 ACE基因缺失多态性在中国高血压病人中可能是脑梗死、脑出血的易患因素 ,并且可能是女性脑梗死患者的危险因素。
Objective To investigate the relationship between the angiotensin converting enzyme (ACE) gene deletion polymorphism and cerebral infarction,hypertensive cerebral hemorrhage in Chinese.Methods With polymerase chain reaction( PCR) method,we detec ted ACE genotypes in 58 patients with cerebral infarction,31 patients with hypertensive cerebral hemorrhage and 60 healthy controls.Results There was significant diffe rence between the frequencies of DD genotype in hypertensive hemorrhage (26%) and healthy controls(P<0.05).There was no significant difference between the frequency of DD genotype in cerebral infarction group (21%) and healthy controls(P>0.05),but the frequencies of DD genotype among cerebral infarction patients with hypertention(27%) and female cerebral infarction patients (26%) had more significant difference than those of healthy controls (P<0.05).Conclusion ACE gene deletion polymorphysm might be a susceptible factor of cerebral infarction and hemorrhage in Chinese patients with hypertension,and might be a risk factor for female patients with cerebral infarction.
出处
《临床神经病学杂志》
CAS
2000年第3期143-145,共3页
Journal of Clinical Neurology
关键词
血管紧张素转化酶
遗传学
脑血管病
Angiotensin converting enzyme Genetics Cerebrovascular disease
