摘要
目的综合评价血管紧张素转换酶(angiotension-converting enzyme,ACE)基因多态性与中国汉族人群缺血性脑卒中(Ischemic Cerebrovascular Disease,ICVD)的关系。方法采用Meta分析的方法,应用随机效应模型和固定效应模型,对16篇关于ACE基因多态性与缺血性脑卒中关系的病例对照研究文献进行综合定量分析。结果Meta分析表明,中国汉族人群携带至少一个D等位基因的个体发生缺血性脑卒中危险性的合并OR值为1.51(1.22,1.85)。携带DD、II基因型的个体发生缺血性脑卒中危险性的合并OR值分别为2.27(1.88,2.74)和0.68(0.50,0.93)。结论ACE基因多态性与我国汉族人群缺血性脑卒中的易感性密切相关。
Objective To evaluate the relationship of angiotensin - converting enzyme （ACE） gene polymorphism to susceptibility of ischemic cerebrovascular disease （ICVD） in Chinese Han population. Methods A comprehensive quantitative analysis was performed by Meta analysis method on 16 control - study literatures about the relationship of ACE gene polymorphism to ICVD, using random effect models and fixed effect models. Results Meta - analysis results showed that the pooled OR value of cerebral ischemic stroke risk was 1.51 （ 1.22, 1. 85 ） in individuals among Han population carrying at least 1 D allele gene, and 2. 27 （ 1.88, 2. 74 ）, 0.68 （ 0. 50, 0. 93 ）, respectively, in individuals carrying DD, Ⅱ gene types. Conclusion ACE gene polymorphism is closely associated with susceptibility of ICVD in Chinese Han population.
出处
《中国全科医学》
CAS
CSCD
北大核心
2009年第22期2036-2039,共4页
Chinese General Practice
关键词
血管紧张素转换酶
缺血性脑卒中
基因
META分析
Angiotensin - converting enzyme
Ischemic Cerebrovascular Disease
Gene
Meta - analysis
