摘要
目的探讨红细胞免疫及天然杀伤细胞（ＮＫＣ）在过敏性紫癜（ＨＳＰ）发病中的可能作用。方法红细胞免疫采用郭峰法测定２２例ＨＳＰ患者，红细胞Ｃ３ｂ受体花环率（ＲＢＣＣ３ｂＲＲ），与免疫复合物受体花环率（ＲＢＣＩＣＲ），流式细胞仪与单克隆抗体（ＣＤ１６）测定ＮＫ细胞的活性。并与２０名正常体检儿童对照。结果ＨＳＰ患者ＲＢＣＣ３ｂＲＲ及ＮＫＣ活性低于正常对照组（Ｐ＜００１），ＲＢＣＩＣＲ高于正常对照组（Ｐ＜００１），ＮＫ细胞与ＲＢＣＣ３ｂＲＲ呈正相关，ｒ＝０９５６，而ＲＢＣＣ３ｂＲＲ与ＲＢＣＩＣＲ呈负相关，ｒ＝１。结论红细胞与ＮＫ细胞可能参与了ＨＳＰ的发病过程，并在ＨＳＰ的病理过程中发挥着重要作用。
Objective To investigate the possible role of red cell c3b reseptor rosette (RBC C3bRR)and red blood cell immune complex rosette(RBC ICR) in the devolopment of HSP.Methods RBC c3bRR and RBC ICR was tested with Guo Feng technique and NKC with flow cytometry in 22 HSP patients and 20 healthy individuals.Results RBC C3bRR and NKC were decreaed significantly,but RBC ICR were elevated in HSP patients,as compared with healthy group ( P <0 01).NKC correlated positively with RBC C3bRR( r =0 956, P <0 001).Conclusion RBC immune and NKC may play an important role in the pathogenesis of HSP.
出处
《中华风湿病学杂志》
CAS
CSCD
1999年第1期44-45,共2页
Chinese Journal of Rheumatology
关键词
过敏性紫癜
天然杀伤细胞
红细胞免疫
Purpura,schoenlein henoch Killer cell,natural Red cell immunity
