期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

CAⅨ、Galectin-3在结肠腺癌组织中的表达及意义 被引量：2

暂未订购
导出
摘要 目的探讨碳酸酐酶Ⅸ(CAⅨ)和半乳糖凝集素3(Galectin-3)在结肠腺癌发生、发展中的作用。方法采用免疫组化SP法检测86份结肠腺癌组织(结肠癌组)、20份结肠管状腺瘤组织(腺瘤组)及20份正常结肠组织(正常组)中CAⅨ和Galectin-3表达,分析其表达与结肠腺癌临床病理特征的关系。结果各组CAⅨ和Galectin-3均有表达,结肠癌组CAⅨ和Galectin-3阳性率均显著高于正常组及腺瘤组(P均<0.05);Galectin-3、CAⅨ阳性表达与结肠腺癌肿瘤体积、淋巴结转移相关(P<0.05),与结肠腺癌患者性别、年龄无相关关系。结论 CAⅨ、Galec-tin-3在结肠腺癌组织中高表达,其可能是结肠腺癌发展的相关因子;CAⅨ、Galectin-3表达可作为预测结肠腺癌浸润、转移和预后的重要指标。
作者 张征 孙哲 段彬彬 陈红 张金库
机构地区 保定市第一中心医院
出处 《山东医药》 CAS 2012年第39期65-67,共3页 Shandong Medical Journal
关键词 碳酸酐酶IX 半乳糖凝集素3 结肠腺癌
分类号 R365 [医药卫生—病理学]
  • 相关文献

参考文献12

  • 1Korkeila E, Talvinen K, Jaakkola PM, et al. Expression of carbonic anhydrase IX suggests poor outcome in rectal cancer[ J]. Br J Canc- er, 2009,1 O0 (6) :874-880.
  • 2Endo K, Kohnoe S, Tsujita E, et al. Galectin-3 expression is a po- tent prognostic marker in colorectal cancer [ J 1. Anticancer Res, 2005,25 (4) :3117-3121,.
  • 3徐跃,杨仙玉.半乳糖凝集素-3及其相关抑制剂的研究进展[J].中国生化药物杂志,2011,32(5):417-420. 被引量：15
  • 4Robertson N, Potter C, Harris AL. Role of carbonic anhydrase IX in human tumor cell growth , survival , and invasion[ J ]. Cancer Res, 2004,64(17) :6160-6165.
  • 5iatromanolaki A, Koukourakis MI, Sivridis E, et al. Expression of tlypoxiainducible carbonic anhydrase-9 relates to angiogenic path-ways and independently to poor outcome in non-small cell lung canc- er[J]. Cancer Res,2001,61 (21) :7992-7998.
  • 6Swinson DE, Jones JL, Richardson D, et al. Carbonic anhydrase IX expression, a novel surrogate marker of tumor hypoxia, is associated with a poor prognosis in non-small-cell lung cancer[J]. J Chn On- col, 2003,21 (3) :473-482.
  • 7Swietach P, Hulikova A. New insights into the physiological role o / carbonic anhydrase IX in tumour pH regulation [ J ]. Oncoqene,[ / 2010,29(50) :6509-6521.
  • 8Fukumori T, Kanayama HO, Raz A. The role of galectin-3 in canc- er drug resistance [ J ]. Drug Resist Updat, 2007,10 ( 3 ) : 101-108.
  • 9Dumic J, Dabelic S, Flgel M. Galectins: an open-ended story[J].Biochim Biophys Acta, 2006,1760(4) :616-635.
  • 10Lin YH, Lin LY, Wu YW, et al. The relationship between serum galectin-3 and serum markers of cardiac extracellular matrix turnover in heart failure patients[J]. Clin Chim Acta, 2009,409(1-2) :96- 99.

二级参考文献53

  • 1雷彩霞,张炜,孙晓炜,杜国平,王丽,刘银坤.Galectin-3表达抑制对子宫内膜上皮细胞生长周期和黏附性的影响[J].复旦学报（医学版）,2007,34(2):169-175. 被引量：12
  • 2程变巧,姜泊,包杰.Galectin-3 shRNA载体的构建表达及其对大肠癌细胞lovo增殖率的影响[J].第四军医大学学报,2007,28(11):1014-1017. 被引量：3
  • 3HSU C G, LIN L Y, KO J L, et al. High expression of human nonmetastatic clone 23 type 1 in cancer of uterine cervix and its association with poor cell differentiation and worse overall survival[J]. JSurg Oncol, 2008, 98(6): 448-456.
  • 4YANG R Y, HSU D K, LIU F T. Expression of galectin-3 modulates T-cell growth and apoptosis[J]. Proc Nat/AcadSci USA, 1996, 93(13): 6737-6742.
  • 5NANGIA-MAKKER P, HONJO Y, SARVIS R, et al. Galectin-3 induces endothelial cell morphogenesis and angiogenesis[J]. Am J Pathol, 2000, 156(3): 899-909.
  • 6SHEKHAR M P, NANGIA-MAKKER P, TAIT L, et al. Alterations in galectin-3 expression and distribution correlate with breast cancer progression: functional analysis of galectin-3 in breast epithelial-endothelial interactions[J]. Am JPathol, 2004, 165(6): 1931-1941.
  • 7MATARRESE P, FUSCO Galectin-3 ove apoptosis by rexpres O, TINARI N, et al. sion protects from mproving cell adhesion properties[J]. Int J Cancer, 2000, 85(4)545-554.
  • 8FUKUMORI T, KANAYAMA H O, RAZ A. The role of galectin-3 in cancer drug resistance[J]. Drug Resist Updat, 2007, 10(3): 101 -108.
  • 9CANESIN G, GONZALEZ-PERAMATO P, PALOU J, et al. Galectin-3 expression is associated with bladder cancer progression and clinical outcome[J]. Tumour Biol, 2010, 31 (4): 277-285.
  • 10SAKAKI M, FUKUMORI T, FUKAWA T, et al Clinical significance of Galectin-3 in clear cel renal cell carcinoma[J].J Med Invest, 2010 57(1/2): 152-157.

共引文献21

同被引文献34

引证文献2

二级引证文献3

山东医药
2012年 第39期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部