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结肠腺癌组织中Nup358的表达及意义

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摘要 目的观察结肠腺癌组织中的核孔素358(Nup358)表达变化,探讨其表达与结肠腺癌临床病理特征之间的关系。方法结肠腺癌患者80例,行左半结肠切除术或右半结肠切除术,术中留取肿瘤组织、癌旁组织(距肿瘤组织5 cm以上的结肠组织)。采用免疫组化Envision染色法检测80例结肠腺癌组织及相应癌旁组织中的Nup358。结果 80例标本中,结肠腺癌组织中Nup358表达阳性56例(70.00%),癌旁组织中表达阳性10例(12.50%),两者相比,P<0.01。结肠腺癌组织中Nup358的表达与结肠癌浸润深度无关(P>0.05),与肿瘤分化程度及淋巴结转移相关,Nup358在低分化者中表达低于高中分化者,在有淋巴结转移者中表达高于无淋巴结转移者(P均<0.05)。结论结肠腺癌组织中Nup358的表达上调,并与结肠腺癌分化程度及淋巴结转移有关。
作者 张小玲 肖胜军 陆竞艳
机构地区 桂林医学院 桂林医学院附属医院
出处 《山东医药》 CAS 2012年第10期73-75,共3页 Shandong Medical Journal
关键词 结肠肿瘤 结肠腺癌 核孔素358
分类号 R735.3 [医药卫生—肿瘤]
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参考文献27

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2012年 第10期

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