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角质形成细胞与皮肤免疫屏障 被引量：15

Keratinocytes and skin immune barrier
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摘要 角质形成细胞(keratinocytes,KC)是皮肤免疫屏障中的重要一员。角质形成细胞可表达模式识别受体(pattern recognitionreceptor,PRR)识别病原体,启动固有免疫反应;角质形成细胞可作为抗原提呈细胞,参与抗原呈递,并分泌多种免疫活性分子参与皮肤免疫防御机制;还可表达抗菌肽直接杀灭或间接活化细胞因子防御病原体。烟酰胺腺嘌呤二核苷酸磷酸(nicoti-namideadeninedinucleotide phosphate,NADPH)氧化酶参与上皮防御的机制则是新的研究热点,其在角质形成细胞的表达及影响因素尚待进一步研究。
作者 万逸枫 蒋献
机构地区 四川大学华西医院皮肤科
出处 《临床皮肤科杂志》 CAS CSCD 北大核心 2012年第11期708-710,共3页 Journal of Clinical Dermatology
关键词 角质形成细胞 皮肤屏障功能 皮肤免疫
分类号 R334.5 [医药卫生—人体生理学]
  • 相关文献

参考文献35

  • 1Goodarzi H, Trowbridge J, Gallo RL. Innate immunity:a cutaneous perspective[J]. Clin Rev Allergy Immunol, 2007, 33(1-2): 15-26.
  • 2Tfinchieri G, Sher A. Cooperation of Toll-like receptor signals in innate immune defcnce[J]. Nat Rev Immunol, 2007, 7(3): 179-190.
  • 3Akira S, Takeda K. Toll-like receptor signalling[J]. Nat Rev Immunol, 2004, 4(7) : 499-511.
  • 4Takeda K, Kaisho T, Akira S. Toll-like receptors[J]. Annu Rev Immunol, 2003, 21: 335-376.
  • 5Lebre MC, Aar AM, Baarsen L, et al. Human keratinocytes express functional Toll-like receptor 3,4,5,and 9 [J]. J Invest Dermatol, 2007, 127(2): 331-341.
  • 6Miller LS. Toll-like receptors in skin[J]. Adv Dermatol, 2008, 24: 71-87.
  • 7Takeuchi O, Hoshino K, Kawai T, et al. Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components[J]. Immunity, 1999, 11(4): 443-451.
  • 8段德鉴,冉玉平,蒋献,李福民,吴琦,周光平.白念珠菌对角质形成细胞Toll样受体2表达的影响[J].中国麻风皮肤病杂志,2005,21(4):256-258. 被引量：2
  • 9Pivarcsi A, Koreck A, Bodai L, et al. Differentiation-regulated expression of Toll-like receptors 2 and 4 in HaCaT keratinocytes[J]. Arch Dermatol Res, 2004, 296(3): 120-124.
  • 10Pivarcsi A, Bodai L, Rethi B, et al. Expression and function of Toll-like receptors 2 and 4 in human keratinocytes [J]. Int Immunol, 2003, 15(6): 721-730.

二级参考文献18

  • 1Yarosh D, Both D, Kibitel, et al. Regulation of TNF alpha production and release in human and mouse skin after UVB irradiation. Photodermatol Photoimmunol Photomed, 2000; 16(6):263.
  • 2Grewe M, Gyufko K, Krutmann J. Interleukin-10 production by cultured human keratinocytes : regulation by ultraviolet B and ultraviolet A1 radiation. J Invest Dermatol, 1995;104(1):3.
  • 3Kondo S. The roles of keratinocyte-derived cytokines in the epidermis and their possible responses to UVA-irradiation. J Invest Dermatol Symp Proc, 1999;4(2):177.
  • 4Clingen PH, Berneburg M, Petit-Frere C, et al. Contrastiong effects of an ultraviolet B and A tanning lamp on Interleukin 6,tumour necrosis factor-alpha and intercellular adhesion molecular-1 expression. Br J Dermatol, 2001;145(1):54.
  • 5Kondo S. The roles of cytokines in photoaging. J Dermatol Sci,2000;23(Suppl 1):S30.
  • 6Park KC, Jung HC, Hwang JH, et al. GM-CSF production by epithelial cell line:upregulation by ultraviolet A. Photodermatol Photoimmunol Photomed, 1997;13(4):133.
  • 7Kondo S, Kono T, Sauder DN, et al. IL-8 expression and production in human keratinocytes and the modulation by UVB.J Invest Dermatol, 1993;101 (5):690.
  • 8Thoma US, Stenger S, Takouchi O, et al. Induction of direct anti-microbial activity through mammalian Toll- like receptors. Science2001 ;291 : 1544 - 1547.
  • 9Pivarcsi A, Bodai L, Rethi B, et al. Expression and function of Toll- like receptor 2 and 4 in human keratinocytes. Int Immunol 2003 ;15 : 721 - 730.
  • 10Takeuchi O, Hoshinok K, Kawai T. Differential roles of TLR2 and TLR4 in recongnition of gram - negative and gram - positive bacterial cell wall components. Immunity 1999; 11:443 - 451.

共引文献7

同被引文献226

引证文献15

二级引证文献223

临床皮肤科杂志
2012年 第11期

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