摘要
目的探讨早产儿视网膜病变（retinopathy of prematurity，ROP）发病情况及相关危险因素。方法回顾性分析2008年12月至2011年2月我院出生的1356例体重2500g以下或胎龄小于37周早产儿的临床资料，分为ROP组（n=208）和非ROP组（n=1148），分析全部早产儿自生后4～6周或矫正胎龄32周筛查眼底改变情况。结果1356例早产儿中，208例发生ROP，发病率为15．34％，其中，严重病变36例（2．65％）。与非ROP组相比，ROP组患儿在出生体重[（1528±243）gVS（1960±187）g]、胎龄[（30．92±0．72）周VS（32．87±1．28）周]、吸氧〉8d（123例VS865例）、应用肺表面活性物质（18例VS216例）、败血症（42例VS154例）、宫内窘迫（63例VS511例）、贫血（64例VS237例）等方面比较，差异有统计学意义（P均〈0．05）。Logistic回归分析结果显示出生体重、胎龄、吸氧〉8d、败血症及应用肺表面活性物质是ROP发生的高危因素（P〈0．05）。同时，不同出生体重、不同胎龄患儿ROP发病率比较，差异均有统计学意义（P〈0．05）。结论出生体重及胎龄越低，ROP发病率越高，病变程度越严重。婴儿出生的成熟度越低，ROP尤其是严重ROP发病可能性越高。
Objective To investigate the present incidence and the risk factors of retinopathy of prematurity （ROP）. Methods The clinical data of 1 356 premature infants who were horn in our hospital from Dec 2008 to Feb 2011 with birth weight of 2 500 g or less and gestational age of 37 weeks or less were analyzed retrospectively, and divided into ROP group （n = 208 ） and without ROP group （n = 1 148 ）. They were screened for ROP from 4 - 6 weeks of chronological age or 32 weeks of postmenstrnal age. Results In 1 356 cases,there were 208 cases with ROP,the incident rate was 15.34% ,of which 36 cases were severe diseases （2. 65% ）. Compared with the infants without ROP,the development of ROP was correlated with birth weight [ （ 1 528 ±243） g vs （ 1 960 ± 187） g] ,gestational age [ （30. 92 ±0. 72） weeks vs （32. 87 ± 1.28） weeks] , oxygen uptake time 〉 8 d （123 cases vs 865 cases） ,pulmonary surfactants （18 cases vs 216 cases） ,septicemia （42 cases vs 154 cases） ,in utero distress （63 cases vs 511 cases） and anemia （64 cases vs 237 cases） （ P 〈 0. 05 ）. Logistic regression analysis suggested that birth weight, gestational age, oxygen uptake time 〉 8 d, septicemia and pulmonary surfactants were significant risk factors associated with the development of ROP （ P 〈 0. 05 ）. Meanwhile, there were significant differences in the incidence of infants with ROP at different birth weight and different gestational age （ P 〈 0. 05 ）. Conclusion The birth weight and gestational age are lower,the incidence of ROP is higher and the disease is more serious. The probability of ROP,particularly severe ROP,is highest in the most immature infants while it is lower in the least immature ones.
出处
《中国小儿急救医学》
CAS
2012年第5期491-493,502,共4页
Chinese Pediatric Emergency Medicine
关键词
早产儿视网膜病变
出生体重
胎龄
Retinopathy of prematurity
Birth weight
Geststional age
