摘要
目的探讨早产儿视网膜病变(retinopathy of prematurity,ROP)与妊娠期危险因素和出生后生长发育状况的关系。方法收集632例孕妇妊娠期相关临床资料,并对这632例胎龄<34周、体质量<1500g的早产、低体质量儿进行ROP筛查,记录符合筛查标准的早产儿的体质量,并检测其脐血和血清IGF-1的水平,运用t检验和卡方检验对数据进行统计学分析。结果 632例早产儿中ROP的患儿为79例,患病率为12.50%。孕妇产前感染、有妊娠期吸烟史和妊娠期并发症产下的早产儿ROP患病率分别为25.00%、40.00%和57.47%,明显高于无产前感染、无妊娠期吸烟史及无妊娠期并发症的患病率(2.41%、11.22%、4.59%,均为P<0.05),出生后低脐血IGF-1和低血清IGF-1水平者ROP患病率(47.62%)明显高于各项正常早产儿患病率(1.58%,均为P<0.05)。结论产前感染、妊娠期吸烟和妊娠期并发症是妊娠期导致ROP发病的高危因素,出生后发育迟缓、低脐血IGF-1和低血清IGF-1水平是影响早产儿ROP发生的高危因素。
Objective To explore the relationship between the occurrence of retinopathy of prematurity（ROP）and hazard factors during pregnancy and extrauterine growth.Methods A total of 632 cases of pregnant women associated clinical data were collected,and 632 infants born with gestation age less than 34 weeks or body weight less than 1500 g were enrolled and underwent ophthalm ologic examination.And the serum IGF-I and umbilical cord blood IGF-1 levels were determined in ROP.Results Among 632 premature infants,79 infants were diagnosed as ROP,the incidence was 12.50%.Pregnant women with prenatal infection,smoking during pregnancy and pregnancy complications produced a significant increase in the incidence of neonatal ROP（25.00% vs 2.41%,40.00% vs 11.22%,57.47% vs 4.59%,all P0.05）.After the birth,extrauterine growth retardation,lower level of IGF-1 in umbilical cord blood and serum were significantly higher than that of normal children（47.62% vs 1.58%,P0.05）.Conclusion Prenatal infection,smoking and pregnancy complications are important risk factors of ROP during pregnancy,extrauterine growth retardation,lower IGF-1 level in umbilical cord blood and serum are important risk factors of ROP after the birth.
出处
《眼科新进展》
CAS
北大核心
2012年第10期976-978,共3页
Recent Advances in Ophthalmology
关键词
早产儿
视网膜病变
妊娠期高危因素
宫外生长发育迟缓
premature infant
retinopathy
high risk factors during pregnancy
extrauterine growth retardation
