摘要
目的研究丹红软肝胶囊对肝纤维化患者分泌转化生长因子β1(TGF-β1)和瘦素的调节作用。方法将108例慢性乙型肝炎患者依据随机数字表法分为两组,治疗组(56例)采用丹红软肝胶囊治疗,对照组(52例)服用复方鳖甲软肝片。治疗6个月,检测治疗前后两组患者的血清TGF-β1和瘦素含量,并进行比较。结果两组治疗后血清TGF-β1和瘦素含量与治疗前相比均明显降低(P<0.01),且两组下降幅度一致,组间比较差异无统计学意义(P>0.05)。结论丹红软肝胶囊可能通过抑制TGF-β1和LP的分泌来抑制肝星形细胞的活化,从而阻止肝纤维化的发展。
Objective To explore influence of Danhong Ruangan capsule on serum transforming growth factor-β1（TGF-β1）level and leptin（LP）level in patients with chronic liver fibrosis.Methods 108 patients with chronic hepatitis B were divided into two groups by random number table,i.e.treatment group and control group.The treatment group（56 cases）was treated with Danhong Ruangan capsule.The control group（52 cases）was treated with Fufang Biejia Ruangan troche.The level of serum TGF-β1 and LP were detected and compared before the treatments started and after the patients had been treated for 24 weeks.Results The level of serum TGF-β1 and leptin of both groups were significantly lower than those before treatment（P〈0.01）.The effects between the two groups had no difference on serum TGF-β1 and LP level（P〈0.05）.Conclusion Danhong Ruangan capsule may inhibit the activation of hepatic stellate cells through inhibition of the secretion of TGF-β1 and LP,which further inhibits the development of liver fibrosis.
出处
《医学综述》
2012年第18期3075-3076,共2页
Medical Recapitulate
基金
邯郸市科学技术研究与发展计划项目(1123108180)
关键词
慢性乙型肝炎
肝纤维化
丹红软肝胶囊
转化生长因子Β1
瘦素
Chronic hepatitis B
Liver fibrosis
Danhong Ruangan capsule
Transforming growth factor-β1
Leptin
