摘要
目的探讨金水宝胶囊治疗尘肺的效果。方法将270例矽肺患者随机分为治疗组和对照组，治疗组141例，对照组129例，两组均给予常规治疗，治疗组在对照组治疗基础上加用金水宝胶囊，3次／a，3粒／次，6周为1个疗程，连续服用2-3个疗程。观察临床效果和肿瘤坏死因子（TNF-α）、转化生长因子（TGF-β1）治疗前后变化情况。结果与对照组比较，治疗组治疗后咳嗽、咳痰、胸痛、气急等呼吸道症状明显改善，差异有统计学意义（P〈0．05）。治疗组TNF-α、TGF-β1水平较治疗前和对照组相比明显降低，差异有统计学意义（P〈0．05）。治疗组治疗后FVC、FEV10、MMEF有所增加，与对照组及治疗组治疗前比较，差异有统计学意义（P〈0．05）。结论金水宝胶囊可降低炎性反应，改善了肺活量及最大通气量，减缓了气流受限，提高了临床疗效及生存质量的作用。
Objective To investigate the therapeutic efficacy of Jinshuibao capsules in the treatment of silicosis. Methods A total of 270 patients with silicosis were randomly divided into treatment group （n=141） and control group （n= 129）. Both groups received conventional therapy. Additionally, the patients in the treatment group took 3 Jinshuibao capsules three times a day for 2-3 courses of treatment （each course=6 weeks）. The therapeutic efficacy and the changes in tumor necrosis factor-or （TNF-α） and transforming growth factor-β1 （TGF-β1） levels were observed after treatment. Results After treatment, cough, expectoration, chest pain, shortness of breath, and other respiratory symptoms were relieved significantly （P〈0.05）. The treatment group showed significantly lower TNF-α and TGF-β1 levels than before treatment and the control group （P〈0.05） and significantly higher forced vital capacity, forced expiratory volume in one second, and maximum mid-expiratory flow than before treatment and the control group （P〈0.05）. Conclusion Jinshuibao capsules can decrease inflammatory response, increase vital capacity and maximum voluntary ventilation, reduce airflow limitation, and improve quality of life and thus have good therapeutic efficacy in the treatment of silicosis.
出处
《中华劳动卫生职业病杂志》
CAS
CSCD
北大核心
2012年第10期781-782,共2页
Chinese Journal of Industrial Hygiene and Occupational Diseases
