摘要
目的了解21种人乳头瘤病毒(human papillomavirus,HPV)型别在云南省妇科门诊人群中的感染情况及型别分布和年龄分布等特点.方法应用基于膜杂交的低密度基因芯片技术对2 221例标本进行分型检测,所得数据用SPSS软件进行统计分析.结果 HPV总感染率为20.76%,高危型HPV感染率18.21%.21种基因型全部检出,其中单一型别感染率为16.21%,2型混合感染率为3.60%,3型(包括3型)以上多重感染率为0.95%.HPV亚型感染率最高的分别是HPV52型4.73%,HPV16型4.05%,HPV58型2.70%,CP8304型2.39%,HPV33型1.53%;各年龄组HPV阳性率组间比较差异无显著性(χ2=9.448,P=0.092).结论本地区人群HPV感染率较高,且以单一亚型感染为主,其中HPV52为高危型HPV感染最主要的型别,低危型HPV感染以CP8304型为主;HPV感染是各年龄段女性共同的致病因素.
Objective To comprehend the status of infection as well as the type distribution and age distribution of Human papillomaviruses（HPV） in women attending Gynaecological outpatient clinics in yunnan and provide evidence for diagnosis and prevention.Methods 2221 samples were detected and genotyped with gene chips.The data were analyzed with the statistical software SPSS.Results 20.76% of those samples were detected positive for HPV infection and 21 HPV genotypes were detected successfully.Among them,16.21% were infected by single HPV genotype,3.61% were infected by two genotypes and 0.95% were infected by three or more genotypes.In the single infection of HPV,the five most prevalent of HPV genotypes were 52,16,58,CP8304 and 33,the infection rate were 4.73%,4.05%,2.70%,2.39% and 1.53% respectively.There was no statistically significant difference in the positive rate between different age groups（χ2=9.448,P=0.092）.Conclusions In Yunnan province,HPV infection rate is high and most are single infection.Among the high risk HPV infections,HPV52 prevalence is highest,and type CP8304 is the most prevalent among the low risk HPV infections.HPV infection seems to be severe in all ages of women.
出处
《昆明医科大学学报》
CAS
2012年第8期73-75,共3页
Journal of Kunming Medical University
基金
云南省科技计划联合专项基金资助项目(40211055)
关键词
人乳头状瘤病毒
分型
宫颈癌
Human papillomaviruses
Types distribution
Cervical cancer
