摘要
目的探讨非小细胞肺癌组织中MMP-2和MMP-9的表达和意义。方法选取非小细胞肺癌组织140例,肺良性疾病组织40例作对照。用聚丙烯酰胺凝胶电泳和免疫组化方法检测其MMP-2和MMP-9的表达。结果肺癌组织中MMP-2阳性率为67.9%,MMP-9表达阳性率为75.0%,显著高于对照组肺组织16.7%和20.0%(P<0.05);MMP-2及MMP-9蛋白与年龄,性别,不同病理类型的阳性率表达差异无显著性(P>0.05);与是否发生淋巴结转移及肺癌TNM分期差异具有显著性(P<0.05)。结论 MMP-2和MMP-9在非小细胞肺癌中表达阳性率较高,在癌症细胞侵润和转移阶段有促进作用,对恶性肺癌的诊断具有重要意义。
【Objective】 To research the clinical significance of MMP-2 and MMP-9 in non-small cell lung cancer.【Methods】 Selected 140 cases of non-small cell lung cancer tissue and 40 cases of health lung tissue as control group.both groups were examined by immunochemistry and westem blotting for the expression of MMP-2 and MMP-9.【Results】 The positive rate of MMP-2 and MMP-9 in non-small cell lung cancer tissue was 75.0%,significantly higher than the control group with 16.7% and 20.0%（P 0.05）;The positive expression of MMP-2 and MMP-9 had correlation with TNM degree,lymphatic metastasis（P 0.05）,but had no correlation with age,gender and different pathological types（P 0.05）.【Conclusion】 MMP-2 and MMP-9 positive rate in non-small cell lung cancer was higher and play an important role in the cancer cells invasion and metastasis,significant on the diagnosis of malignant lung cancer.
出处
《中国现代医学杂志》
CAS
CSCD
北大核心
2012年第24期49-51,共3页
China Journal of Modern Medicine
